Design, synthesis, antibacterial activity and toxicity of novel quaternary ammonium compounds based on pyridoxine and fatty acids

SV Sapozhnikov, AE Sabirova, NV Shtyrlin… - European Journal of …, 2021 - Elsevier
A diverse series of 43 novel “soft antimicrobials” based on quaternary ammonium pyridoxine
derivatives which include six-membered acetals and ketals of pyridoxine bound via …

2-Amino-3, 5-dicarbonitrile-6-sulfanylpyridines: synthesis and multiple biological activity–a review

NS Akhmadiev, VR Akhmetova, AG Ibragimov - RSC advances, 2021 - pubs.rsc.org
This review integrates the published data of the last decade (from 2010 to 2020) on the
synthesis of the 2-amino-3, 5-dicarbonitrile-6-sulfanylpyridine scaffold, the derivatives of …

Sustainable and bio-based catalysts for multicomponent organic synthesis: An overview

M Hamidinasab, N Ahadi, MA Bodaghifard… - Polycyclic Aromatic …, 2023 - Taylor & Francis
The design and development of eco-friendly procedures for synthesizing organic
compounds is an essential key to synthetic chemistry and has gained significant interest …

Novel bis-ammonium salts of pyridoxine: Synthesis and antimicrobial properties

NV Shtyrlin, MV Pugachev, SV Sapozhnikov… - Molecules, 2020 - mdpi.com
A series of 108 novel quaternary bis-ammonium pyridoxine derivatives carrying various
substituents at the quaternary nitrogen's and acetal carbon was synthesized. Thirteen …

Chemical Modifications of Pyridoxine for Biological Applications: An Overview

R Pawar, P Chaudhran, D Pandey… - Current Topics in …, 2023 - ingentaconnect.com
Pyridoxine and its derivatives, pyridoxamine, and pyridoxal have been recognized for more
than 70 years and are known for regulating cellular biology and metabolism. During the past …

Reactions of malononitrile dimer with isothiocyanates

VV Dotsenko, AV Bespalov, AA Russkikh… - Russian Journal of …, 2021 - Springer
Abstract The reaction of 2-amino-1, 1, 3-tricyanopropene (malononitrile dimer) with
isothiocyanates leads to 1-substituted 4, 6-diamino-2-thioxo-1, 2-dihydropyridine-3, 5 …

One-pot synthesis of quaternary pyridinium salts of lupane triterpenoids and their antimicrobial properties

ER Shakurova, SS Efimova, OS Ostroumova… - New Journal of …, 2023 - pubs.rsc.org
C30-quaternized derivatives of lupane triterpenoids (31 examples) were synthesized with a
yield of 85–95% via a one-pot functionalization of a double bond under the action of organic …

Synthesis and Aminomethylation of 6-Amino-2-(dicyanomethylene)-4-phenyl-1, 2-dihydropyridine-3, 5-dicarbonitrile morpholinium salt

AO Kurskova, VV Dotsenko, KA Frolov… - Russian Journal of …, 2021 - Springer
Condensation of benzaldehyde with malononitrile and malononitrile dimer (2-aminopropene-
1, 1, 3-tricarbonitrile) in the presence of an excess of morpholine in ethanol afforded the …

Montmorillonite K10 Clay Accelerated One‐Pot Multicomponent Synthesis of Substituted 2‐Amino‐3, 5‐dicarbonitrile‐6‐phenylsulfanylpyridines: Experimental and …

P Sharma, P Sinha - ChemistrySelect, 2023 - Wiley Online Library
Amino‐3, 5‐dicarbonitrile‐6‐phenylsulfanylpyridines occupy a prominent place among the
physiologically and biologically active scaffolds owing to their therapeutic applications in the …

An efficient four-component protocol for synthesis of poly-substituted pyridines with SiO2 as a robust recyclable catalyst

VN Chandra Sekhar, G Simhachalam… - Synthetic …, 2024 - Taylor & Francis
A four-component protocol for the development of poly-substituted pyridines derivatives by
using SiO2 as a recycle catalyst. The protocol offers good to excellent yields (85%-95%) …