RAS nanoclusters are cell surface transducers that convert extracellular stimuli to intracellular signalling
Y Zhou, JF Hancock - FEBS letters, 2023 - Wiley Online Library
Mutations of rat sarcoma virus (RAS) oncogenes (HRAS, KRAS and NRAS) can contribute to
the development of cancers and genetic disorders (RASopathies). The spatiotemporal …
the development of cancers and genetic disorders (RASopathies). The spatiotemporal …
[HTML][HTML] Location, location, location: Protein kinase nanoclustering for optimised signalling output
Protein kinases (PKs) are proteins at the core of cellular signalling and are thereby
responsible for most cellular physiological processes and their regulations. As for all …
responsible for most cellular physiological processes and their regulations. As for all …
RAS G-domains allosterically contribute to the recognition of lipid headgroups and acyl chains
Mutant RAS are major contributors to cancer and signal primarily from nanoclusters on the
plasma membrane (PM). Their C-terminal membrane anchors are main features of …
plasma membrane (PM). Their C-terminal membrane anchors are main features of …
RAS GTPases and Interleaflet Coupling in the Plasma Membrane
RAS genes are frequently mutated in cancer. The primary signaling compartment of wild-
type and constitutively active oncogenic mutant RAS proteins is the inner leaflet of the …
type and constitutively active oncogenic mutant RAS proteins is the inner leaflet of the …
Fast and Multiplexed Super Resolution Imaging of Fixed and Immunostained Cells with DNA‐PAINT‐ERS
Recent advances in super resolution microscopy have enabled imaging at the 10‐20 nm
scale on a light microscope, providing unprecedented details of native biological structures …
scale on a light microscope, providing unprecedented details of native biological structures …
Lysophosphatidylcholine acyltransferase 1 suppresses nanoclustering and function of KRAS
KRAS is frequently mutated in cancer, contributing to 20% of all human cancer especially
pancreatic, colorectal and lung cancer. Signaling of the constitutively active KRAS …
pancreatic, colorectal and lung cancer. Signaling of the constitutively active KRAS …
[PDF][PDF] Hydrolysis of Phospholipids in Presence of Phospholipase D: Thrmodynamic and Kinetic Studies of Hydrolysis in Water and Alcoholic Environments
IS Hussein, TMM Al-Rammahi - Al-Nahrain Journal of Science, 2024 - iasj.net
Phospholipase D (PLD) catalyzes the hydrolysis of phospholipids to produce phosphatidic
acid and hydroxyl compounds. Phosphatidylcholine (PC) is the most abundant phospholipid …
acid and hydroxyl compounds. Phosphatidylcholine (PC) is the most abundant phospholipid …