Purinergic signalling: therapeutic developments
G Burnstock - Frontiers in pharmacology, 2017 - frontiersin.org
Purinergic signalling, ie, the role of nucleotides as extracellular signalling molecules, was
proposed in 1972. However, this concept was not well accepted until the early 1990's when …
proposed in 1972. However, this concept was not well accepted until the early 1990's when …
Historical and current adenosine receptor agonists in preclinical and clinical development
KA Jacobson, DK Tosh, S Jain, ZG Gao - Frontiers in cellular …, 2019 - frontiersin.org
Adenosine receptors (ARs) function in the body's response to conditions of pathology and
stress associated with a functional imbalance, such as in the supply and demand of …
stress associated with a functional imbalance, such as in the supply and demand of …
Adenosine signalling in diabetes mellitus—pathophysiology and therapeutic considerations
Adenosine is a key extracellular signalling molecule that regulates several aspects of tissue
function by activating four G-protein-coupled receptors, A1, A2A, A2B and A1 adenosine …
function by activating four G-protein-coupled receptors, A1, A2A, A2B and A1 adenosine …
Wildfire smoke exposure during pregnancy: a review of potential mechanisms of placental toxicity, impact on obstetric outcomes, and strategies to reduce exposure
Climate change is accelerating the intensity and frequency of wildfires globally.
Understanding how wildfire smoke (WS) may lead to adverse pregnancy outcomes and …
Understanding how wildfire smoke (WS) may lead to adverse pregnancy outcomes and …
Exposome and foetoplacental vascular dysfunction in gestational diabetes mellitus
A balanced communication between the mother, placenta and foetus is crucial to reach a
successful pregnancy. Several windows of exposure to environmental toxins are present …
successful pregnancy. Several windows of exposure to environmental toxins are present …
The impact of oxidative stress of environmental origin on the onset of placental diseases
CSM Ruano, F Miralles, C Méhats, D Vaiman - Antioxidants, 2022 - mdpi.com
Oxidative stress (OS) plays a pivotal role in placental development; however, abnormal
loads in oxidative stress molecules may overwhelm the placental defense mechanisms and …
loads in oxidative stress molecules may overwhelm the placental defense mechanisms and …
Gestational diabetes mellitus placentas exhibit epimutations at placental development genes
Gestational diabetes mellitus (GDM) is a maternal metabolic disorder that perturbs placental
development and increases the risk of offspring short-and long-term metabolic disorders …
development and increases the risk of offspring short-and long-term metabolic disorders …
Insulin receptor isoforms: an integrated view focused on gestational diabetes mellitus
The human insulin receptor (IR) exists in two isoforms that differ by the absence (IR‐A) or the
presence (IR‐B) of a 12‐amino acid segment encoded by exon 11. Both isoforms are …
presence (IR‐B) of a 12‐amino acid segment encoded by exon 11. Both isoforms are …
[HTML][HTML] Role of insulin, adenosine, and adipokine receptors in the foetoplacental vascular dysfunction in gestational diabetes mellitus
M Subiabre, R Villalobos-Labra, L Silva… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Gestational diabetes mellitus (GDM) is a disease of pregnancy associated with maternal and
foetal hyperglycaemia and altered foetoplacental vascular function. Human foetoplacental …
foetal hyperglycaemia and altered foetoplacental vascular function. Human foetoplacental …
Adenosine receptors and diabetes: focus on the A2B adenosine receptor subtype
Over the last two decades, diabetes mellitus has become one of the most challenging health
problems worldwide. Diabetes mellitus, classified as type I and II, is a pathology concerning …
problems worldwide. Diabetes mellitus, classified as type I and II, is a pathology concerning …