NQO1: A target for the treatment of cancer and neurological diseases, and a model to understand loss of function disease mechanisms
SK Beaver, N Mesa-Torres, AL Pey… - Biochimica et Biophysica …, 2019 - Elsevier
Abstract NAD (P) H quinone oxidoreductase 1 (NQO1) is a multi-functional protein that
catalyses the reduction of quinones (and other molecules), thus playing roles in xenobiotic …
catalyses the reduction of quinones (and other molecules), thus playing roles in xenobiotic …
Targeting HIF-1α function in cancer through the chaperone action of NQO1: implications of genetic diversity of NQO1
HIF-1α is a master regulator of oxygen homeostasis involved in different stages of cancer
development. Thus, HIF-1α inhibition represents an interesting target for anti-cancer therapy …
development. Thus, HIF-1α inhibition represents an interesting target for anti-cancer therapy …
[HTML][HTML] Analysis of missense variants in the human genome reveals widespread gene-specific clustering and improves prediction of pathogenicity
We used a machine learning approach to analyze the within-gene distribution of missense
variants observed in hereditary conditions and cancer. When applied to 840 genes from the …
variants observed in hereditary conditions and cancer. When applied to 840 genes from the …
The catalytic cycle of the antioxidant and cancer-associated human NQO1 enzyme: Hydride transfer, conformational dynamics and functional cooperativity
Human NQO1 [NAD (H): quinone oxidoreductase 1] is a multi-functional and stress-
inducible dimeric protein involved in the antioxidant defense, the activation of cancer …
inducible dimeric protein involved in the antioxidant defense, the activation of cancer …
Impact of NQO1 dysregulation in CNS disorders
L Yuhan, M Khaleghi Ghadiri, A Gorji - Journal of Translational Medicine, 2024 - Springer
Abstract NAD (P) H Quinone Dehydrogenase 1 (NQO1) plays a pivotal role in the regulation
of neuronal function and synaptic plasticity, cellular adaptation to oxidative stress …
of neuronal function and synaptic plasticity, cellular adaptation to oxidative stress …
Effect of naturally-occurring mutations on the stability and function of cancer-associated NQO1: Comparison of experiments and computation
JL Pacheco-Garcia, M Cagiada… - Frontiers in Molecular …, 2022 - frontiersin.org
Recent advances in DNA sequencing technologies are revealing a large individual
variability of the human genome. Our capacity to establish genotype-phenotype correlations …
variability of the human genome. Our capacity to establish genotype-phenotype correlations …
Insights into the pathogenesis of primary hyperoxaluria type I from the structural dynamics of alanine: glyoxylate aminotransferase variants
P Vankova, JL Pacheco‐Garcia, DS Loginov… - FEBS …, 2024 - Wiley Online Library
Primary hyperoxaluria type I (PH1) is caused by deficient alanine: glyoxylate
aminotransferase (AGT) activity. PH1‐causing mutations in AGT lead to protein mistargeting …
aminotransferase (AGT) activity. PH1‐causing mutations in AGT lead to protein mistargeting …
A dynamic core in human NQO1 controls the functional and stability effects of ligand binding and their communication across the enzyme dimer
Human NAD (P) H: quinone oxidoreductase 1 (NQO1) is a multi-functional protein whose
alteration is associated with cancer, Parkinson's and Alzheimer´ s diseases. NQO1 displays …
alteration is associated with cancer, Parkinson's and Alzheimer´ s diseases. NQO1 displays …
Biochemical and cellular effects of a novel missense mutation of the AGXT gene associated with Primary Hyperoxaluria Type 1
Abstract Primary Hyperoxaluria Type 1 (PH1) is a rare autosomal disease caused by
mutations in AGXT that lead to the deficiency of alanine: glyoxylate aminotransferase (AGT) …
mutations in AGXT that lead to the deficiency of alanine: glyoxylate aminotransferase (AGT) …
Counterintuitive structural and functional effects due to naturally occurring mutations targeting the active site of the disease‐associated NQO1 enzyme
JL Pacheco‐García, E Anoz‐Carbonell… - The FEBS …, 2023 - Wiley Online Library
Our knowledge on the genetic diversity of the human genome is exponentially growing.
However, our capacity to establish genotype–phenotype correlations on a large scale …
However, our capacity to establish genotype–phenotype correlations on a large scale …