Abstract Myotonic dystrophy type 1 (DM1) is a dominant multisystemic disorder associated
with high variability of symptoms and anticipation. DM1 is caused by an unstable CTG …

Myotonic dystrophy type 1 (DM1) exhibits highly heterogeneous clinical manifestations
caused by an unstable CTG repeat expansion reaching up to 4000 CTG. The clinical …

Myotonic dystrophy type 1 (DM1), the most frequent inherited muscular dystrophy in adults,
is caused by the CTG repeat expansion in the 3′ UTR of the DMPK gene. Mutant DMPK …

Numerous human diseases are associated with abnormal expansion of unstable
trinucleotide repeats (TNRs). TNR instability mechanisms are complex, and remain only …

Trinucleotide repeats are a peculiar class of microsatellites involved in many neurological as
well as developmental disorders. Their propensity to generate very large expansions over …

Molecular ecology uses molecular genetic data to answer traditional ecological questions in
biogeography and biodiversity, among others. Several ecological principles, such as the …

Introduction Myotonic dystrophy type 1 (DM1) is a multisystemic disorder characterized
mainly by skeletal muscle alterations. Although oropharyngeal dysphagia is a prominent …

En México cerca de seis millones de personas presentan algún tipo de discapacidad,
siendo las enfermedades neuromusculares (ENM) una de las causas más frecuentes de …

Die hier vorliegende Promotionsarbeit hatte die Etablierung einer nicht-radioaktiven
Methodik zur quantitativen Bestimmung von CTG-Repeats in Muskelgewebe von Patienten …

La distrofia miotónica tipo 1 (DM1) es la distrofia más común en adultos. La enfermedad es
causada por alelos que sobrepasan un umbral de aproximadamente 50 repetidos y que …