Dietary restriction and lifespan: Lessons from invertebrate models

P Kapahi, M Kaeberlein, M Hansen - Ageing research reviews, 2017 - Elsevier
Dietary restriction (DR) is the most robust environmental manipulation known to increase
active and healthy lifespan in many species. Despite differences in the protocols and the …

[HTML][HTML] Reproduction, fat metabolism, and life span: what is the connection?

M Hansen, T Flatt, H Aguilaniu - Cell metabolism, 2013 - cell.com
Reduced reproduction is associated with increased fat storage and prolonged life span in
multiple organisms, but the underlying regulatory mechanisms remain poorly understood …

[图书][B] Mechanisms of life history evolution: the genetics and physiology of life history traits and trade-offs

T Flatt, A Heyland - 2011 - books.google.com
Life history theory seeks to explain the evolution of the major features of life cycles by
analyzing the ecological factors that shape age-specific schedules of growth, reproduction …

Understanding insect life histories and senescence through a resource allocation lens

CL Boggs - Functional Ecology, 2009 - Wiley Online Library
Summary 1 Resource acquisition and allocation are the physiological mechanisms
integrating foraging and life‐history traits. An understanding of the patterns of acquisition …

Immunity in a variable world

BP Lazzaro, TJ Little - … of the Royal Society B: Biological …, 2009 - royalsocietypublishing.org
Immune function is likely to be a critical determinant of an organism's fitness, yet most
natural animal and plant populations exhibit tremendous genetic variation for immune traits …

Repeated stress exposure results in a survival–reproduction trade-off in Drosophila melanogaster

KE Marshall, BJ Sinclair - Proceedings of the Royal …, 2010 - royalsocietypublishing.org
While insect cold tolerance has been well studied, the vast majority of work has focused on
the effects of a single cold exposure. However, many abiotic environmental stresses …

Desiccation and starvation resistance in Drosophila: patterns of variation at the species, population and intrapopulation levels

AA Hoffmann, LG Harshman - Heredity, 1999 - nature.com
A substantial number of Drosophila studies have investigated variation in desiccation and
starvation resistance, providing an opportunity to test for consistent patterns of direct and …

Correlated responses to selection for stress resistance and longevity in a laboratory population of Drosophila melanogaster

OA Bubliy, V Loeschcke - Journal of evolutionary biology, 2005 - academic.oup.com
Laboratory studies on Drosophila have revealed that resistance to one environmental stress
often correlates with resistance to other stresses. There is also evidence on genetic …

Evolutionary biology of starvation resistance: what we have learned from Drosophila

S Rion, TJ Kawecki - Journal of evolutionary biology, 2007 - academic.oup.com
Most animals face periods of food shortage and are thus expected to evolve adaptations
enhancing starvation resistance (SR). Most of our knowledge of the genetic and …

A glucagon-like endocrine pathway in Drosophila modulates both lipid and carbohydrate homeostasis

KN Bharucha, P Tarr… - Journal of Experimental …, 2008 - journals.biologists.com
The regulation of energy homeostasis is fundamental to all organisms. The Drosophila fat
body serves as a repository for both triglycerides and glycogen, combining the energy …