Thirty-four years since its discovery, NF-κB remains a transcription factor with great potential
for cancer therapy. However, NF-κB–targeted therapies have yet to find a way to be clinically …

Cytokines are pivotal mediators of the immune response, and their coordinated expression
protects host tissue from excessive damage and oxidant stress. Nevertheless, the …

Background Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell
lung cancer. Ferroptosis is a newly recognized process of cell death, which is different from …

Lung cancer and chronic lung diseases impose major disease burdens worldwide and are
caused by inhaled noxious agents including tobacco smoke. The cellular origins of …

Nuclear factor kappa B (NF-κB), a key nuclear transcription factor, is associated with
prognosis in a variety of human cancers. However, the clinical value of NF-κB in non-small …

Long non-coding RNAs (lncRNAs) expression profile signature for survival assessment in
lung squamous cell carcinoma (LUSC) are largely inconsistent due to distinct detecting …

Papillomaviruses induce a range of benign and malignant lesions in their hosts, including
cervical cancer, that is associated with high-risk human papillomavirus (HPV) types. The …

Although oncogenic activation of NFκB has been identified in various tumors, the NFκB–
activating kinases (inhibitor of NFκB kinases, IKK) responsible for this are elusive. In this …

Malignant pleural effusion (MPE) is a frequent metastatic manifestation of human cancers.
While we previously identified KRAS mutations as molecular culprits of MPE formation, the …

In this mini-review, we discuss the role of NF-κB, a proinflammatory transcription factor, in
the expression of genes involved in inflammation, proliferation, and apoptosis pathways …