Insulin-like growth factors (IGFs) are peptides which exert mitogenic, endocrine and cytokine
activities. Together with their receptors, binding proteins and associated molecules, they …

Reconstruction of large bone defects remains a clinical challenge because current
approaches involving surgery and bone grafting often do not yield satisfactory outcomes. For …

Genetic variation in the insulin‐like growth factor (IGF) pathway may further increase the risk
of colorectal cancer (CRC) associated with type 2 diabetes mellitus (T2DM). Joint effects of …

Early detection of colorectal neoplasms can reduce the disease burden of colorectal cancer
by timely intervention of individuals at high risk. Our aim was to evaluate a joint …

Physical activity is associated with a lower risk of disease recurrence among colon cancer
survivors. The pathways through which physical activity may alter disease outcomes are …

Higher circulating 25-hydroxyvitamin D levels (25 (OH) D) have been found to be associated
with lower risk for colorectal cancer (CRC) in prospective studies. Whether this association is …

Background. Insulin-like growth factor 1 (IGF-1) is known as somatomedin C. This
polypeptide hormone is functionally and structurally similar to insulin. IGF-1 effects on tissue …

The mechanism of gender disparity in cutaneous melanoma incidence remains unclear.
Steroid hormones including estrogens have long been implicated in the course of …

Background: We hypothesized that the risk of colorectal cancer in night-shift workers might
be different according to insulin receptor substrate status. Methods: Among 77,470 eligible …

Background The receptors, ligands, and associated proteins of the insulin-like growth factor
(IGF) family are involved in cancer development. The IGF1 receptor and its accompanying …