Next-generation DNA sequencing technology has dramatically advanced clinical oncology
through the identification of therapeutic targets and molecular biomarkers, leading to the …

The PEA3 subfamily is a subgroup of the E26 transformation-specific (ETS) family. Its
members, ETV1, ETV4, and ETV5, have been found to be overexpressed in multiple …

A large number of putative cis-regulatory sequences have been annotated in the human
genome, but the genes they control remain poorly defined. To bridge this gap, we generate …

Cancer is characterized by pervasive epigenetic alterations with enhancer dysfunction
orchestrating the aberrant cancer transcriptional programs and transcriptional …

Genetic studies have advanced our understanding of pancreatic cancer at a mechanistic
and translational level. Genetic concepts and tools are increasingly starting to be applied to …

Background And Aims Susceptibility genes and the underlying mechanisms for the majority
of risk loci identified by genome-wide association studies (GWAS) for colorectal cancer …

Genome-wide association studies (GWAS) have identified more than 200 common genetic
variants independently associated with colorectal cancer (CRC) risk, but the causal variants …

Genome-wide association studies (GWASs) have identified over 140 colorectal cancer
(CRC)-associated loci; however, target genes at the majority of loci and underlying …

The Chinese hamster genome serves as a reference genome for the study of Chinese
hamster ovary (CHO) cells, the preferred host system for biopharmaceutical production …

Abnormal activities of distal cis-regulatory elements (CREs) contribute to the initiation and
progression of cancer. Gain of super-enhancer (SE), a highly active distal CRE, is essential …