Patients with advanced cancer generate 4 million visits annually to emergency departments
(EDs) and other dedicated, high‐acuity oncology urgent care centers. Because of both the …

Neuroendocrine neoplasms (NENs) are a group of heterogeneous tumors with
neuroendocrine differentiation that can arise from any organ. They account for 2% of all …

Insulin, a small protein with 51 amino acids synthesized by pancreatic β-cells, is crucial to
sustain glucose homeostasis at biochemical and molecular levels. Numerous metabolic …

Pancreatic neuroendocrine neoplasms (panNENs) are rare relatively malignancies that,
despite their frequently slow-growing pattern, have the ability to metastasize. Metastatic …

Abstract Knowledge of ectopic insulinomas comes from single cases. We performed a
systematic review through PubMed, Web of Science, Embase, eLibrary and ScienceDirect of …

5-Azacytidine (5-azaC), a methyltransferase inhibitor and anticancer drug, can promote
several cellular stress responses such as apoptosis, autophagy, and senescence. The …

Opinion statement Given the considerable heterogeneity in neuroendocrine neoplasms
(NENs), it appears unlikely that a sole biomarker exists capable of fully capturing all useful …

Pancreatic neuroendocrine tumors (PNETs) arise from endocrine pancreatic cells and
comprise 3-5% of pancreatic cancers. Surgical resection is the only potentially curative …

Insulinoma and glucagonoma are two rare functioning neoplasms of the neuroendocrine
cells of the pancreas, respectively, characterized by an uncontrolled over-secretion of insulin …

Background Insulinomas are usually benign, small-sized, well-encapsulated and often
solitary pancreatic tumors. Currently, enucleation is the treatment of choice for sporadic …