The conditioned place preference (CPP) paradigm is a well-established model utilized to
study the role of context associations in reward-related behaviors, including both natural …

Conditioned place preference (CPP) continues to be one of the most popular models to
study the motivational effects of drugs and non‐drug treatments in experimental animals …

Drug dependence is a chronic, relapsing disorder in which compulsive drug-seeking and
drug-taking behaviours persist despite serious negative consequences. Addictive …

This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

Addictive drugs induce a dopamine signal that contributes to the initiation of addiction, and
the dopamine signal influences drug-associated memories that perpetuate drug use. The …

In the search for efficacious pharmacotherapies to treat cocaine addiction much attention
has been given to agents targeting dopamine D1 or D3 receptors because of the …

Chronic exposure to opiates impairs hippocampal long-term potentiation (LTP) and spatial
memory, but the underlying mechanisms remain to be elucidated. Given the well known …

Cocaine abusers may experience drug craving upon exposure to environmental contexts
where cocaine was experienced. The dorsal hippocampus (DHC) is important for contextual …

The long lasting addiction-related abnormal memory is one of the most important
foundations for relapse. DNA methylation may be a possible mechanism for persistence of …

Addictive drugs have been shown to severely influence many neuronal functions, which are
considered as the underlying mechanisms for physiological and psychological …