The foundations of immune checkpoint blockade and the ipilimumab approval decennial
AJ Korman, SC Garrett-Thomson… - Nature Reviews Drug …, 2022 - nature.com
Cancer immunity, and the potential for cancer immunotherapy, have been topics of scientific
discussion and experimentation for over a hundred years. Several successful cancer …
discussion and experimentation for over a hundred years. Several successful cancer …
Programmed death ligand 1 signals in cancer cells
The paradigm of surface-expressed programmed death ligand 1 (PDL1) signalling to
immune cell programmed death 1 (PD1) to inhibit antitumour immunity has helped to …
immune cell programmed death 1 (PD1) to inhibit antitumour immunity has helped to …
Non-viral, specifically targeted CAR-T cells achieve high safety and efficacy in B-NHL
J Zhang, Y Hu, J Yang, W Li, M Zhang, Q Wang… - Nature, 2022 - nature.com
Recently, chimeric antigen receptor (CAR)-T cell therapy has shown great promise in
treating haematological malignancies,,,,,–. However, CAR-T cell therapy currently has …
treating haematological malignancies,,,,,–. However, CAR-T cell therapy currently has …
Photocatalysis in the life science industry
L Candish, KD Collins, GC Cook, JJ Douglas… - Chemical …, 2021 - ACS Publications
In the pursuit of new pharmaceuticals and agrochemicals, chemists in the life science
industry require access to mild and robust synthetic methodologies to systematically modify …
industry require access to mild and robust synthetic methodologies to systematically modify …
Thermal immuno-nanomedicine in cancer
Immunotherapy has revolutionized the treatment of patients with cancer. However,
promoting antitumour immunity in patients with tumours that are resistant to these therapies …
promoting antitumour immunity in patients with tumours that are resistant to these therapies …
Reducing affinity as a strategy to boost immunomodulatory antibody agonism
Antibody responses during infection and vaccination typically undergo affinity maturation to
achieve high-affinity binding for efficient neutralization of pathogens,. Similarly, high affinity …
achieve high-affinity binding for efficient neutralization of pathogens,. Similarly, high affinity …
PD-L1 positive astrocytes attenuate inflammatory functions of PD-1 positive microglia in models of autoimmune neuroinflammation
M Linnerbauer, T Beyer, L Nirschl, D Farrenkopf… - Nature …, 2023 - nature.com
Multiple Sclerosis (MS) is a chronic autoimmune inflammatory disorder of the central
nervous system (CNS). Current therapies mainly target inflammatory processes during acute …
nervous system (CNS). Current therapies mainly target inflammatory processes during acute …
Extracellular vesicle PD-L1 dynamics predict durable response to immune-checkpoint inhibitors and survival in patients with non-small cell lung cancer
Abstract Background Immune-checkpoint inhibitors (ICIs) changed the therapeutic
landscape of patients with lung cancer. However, only a subset of them derived clinical …
landscape of patients with lung cancer. However, only a subset of them derived clinical …
PTP1B is an intracellular checkpoint that limits T-cell and CAR T-cell antitumor immunity
Immunotherapies aimed at alleviating the inhibitory constraints on T cells have
revolutionized cancer management. To date, these have focused on the blockade of cell …
revolutionized cancer management. To date, these have focused on the blockade of cell …
Combined angiogenesis and PD-1 inhibition for immunomodulatory TNBC: concept exploration and biomarker analysis in the FUTURE-C-Plus trial
SY Wu, Y Xu, L Chen, L Fan, XY Ma, S Zhao, XQ Song… - Molecular cancer, 2022 - Springer
Background Immune checkpoint inhibitors had a great effect in triple-negative breast cancer
(TNBC); however, they benefited only a subset of patients, underscoring the need to co …
(TNBC); however, they benefited only a subset of patients, underscoring the need to co …