Hierarchy is a major organizational principle of the cortex and underscores modern
computational theories of cortical function. The local microcircuit amplifies long-distance …

Radial cell columns are a hallmark feature of cortical architecture in many mammalian
species. It has long been held, based on the lack of orientation columns, that such functional …

Recent advances in connectomics and neurophysiology make it possible to probe whole-
brain mechanisms of cognition and behavior. We developed a large-scale model of the …

The role of experience in the organization of cortical feedback (FB) remains unknown. We
measured the effects of manipulating visual experience on the retinotopic specificity of …

If a full visual percept can be said to be a 'hypothesis', so too can a neural 'prediction'–
although the latter addresses one particular component of image content (such as 3 …

The sensory neocortex consists of hierarchically-organized areas reciprocally connected via
feedforward and feedback circuits. Feedforward connections shape the receptive field …

Inter-areal coherence has been hypothesized as a mechanism for inter-areal
communication. Indeed, empirical studies have observed an increase in inter-areal …

Sensory cortical areas are organized into topographic maps representing the sensory
epithelium. Interareal projections typically connect topographically matched subregions …

The idea of columns as an organizing cortical unit emerged from physiologic studies in the
sensory systems. Connectional studies and molecular markers pointed to widespread …

Rabies viral vectors have become important components of the systems neuroscience
toolkit, allowing both direct retrograde targeting of projection neurons and monosynaptic …