The brain has a remarkable but underappreciated capacity to limit memory formation and
expression. The term" memory suppressor gene" was coined in 1998 as an attempt to …

Autophagy provides nutrients during starvation and eliminates detrimental cellular
components. However, accumulating evidence indicates that autophagy is not merely a …

Trithorax-related H3K4 methyltransferases, KMT2C and KMT2D, are critical epigenetic
modifiers. Haploinsufficiency of KMT2C was only recently recognized as a cause of …

Membrane channels such as those formed by connexins (Cx) and P2X7 receptors (P2X7R)
are permeable to calcium ions and other small molecules such as adenosine triphosphate …

Background: DNA methylation (DNAm), an epigenetic mark reflecting both inherited and
environmental influences, has shown promise for Alzheimer's disease (AD) prediction …

The histone lysine demethylase KDM5B is implicated in recessive intellectual disability
disorders, and heterozygous, protein-truncating variants in KDM5B are associated with …

Molecular mechanisms underlying cognitive deficits in Huntington's disease (HD), a striatal
neurodegenerative disorder, are unknown. Here, we generated ChIPseq, 4Cseq and …

Neuroplasticity in the amygdala and its central nucleus (CeA) is linked to pain modulation
and pain behaviors, but cellular mechanisms are not well understood. Here, we addressed …

Purpose Hypertensive lesions induce alterations at hemodynamic, peripheral, and central
levels. Anandamide (N-arachidonoylethanolamine; AEA) protects neurons from …

Spatial learning and memory flexibility are known to require long-term potentiation (LTP)
and long-term depression (LTD), respectively, on a cellular basis. We previously showed …