The TGF-β regulatory system plays crucial roles in the preservation of organismal integrity.
TGF-β signaling controls metazoan embryo development, tissue homeostasis, and injury …

Myeloid cells in the central nervous system (CNS), such as microglia, CNS-associated
macrophages (CAMs), dendritic cells and monocytes, are vital for steady-state immune …

The APOE4 allele is the strongest genetic risk factor for late-onset Alzheimer's disease (AD).
The contribution of microglial APOE4 to AD pathogenesis is unknown, although APOE has …

Central nervous system (CNS) macrophages comprise microglia and border-associated
macrophages (BAMs) residing in the meninges, the choroid plexus, and the perivascular …

Microglial surveillance is a key feature of brain physiology and disease. Here, we found that
Gi-dependent microglial dynamics prevent neuronal network hyperexcitability. By …

As the resident macrophages of the brain and spinal cord, microglia are crucial for the
phagocytosis of infectious agents, apoptotic cells and synapses. During brain injury or …

Advances in human genetics have implicated a growing number of genes in
neurodegenerative diseases, providing insight into pathological processes. For Alzheimer …

Summary Cx3cr1 CreER-driven Cre recombinase (Cre) is a widely used genetic tool for
enabling gene manipulation in microglia and macrophages. However, an in-depth analysis …

The pleiotropic cytokine transforming growth factor-beta 1 (TGFβ1) plays pivotal roles in
different cell types, including immune cells such as T cells, monocytes/macrophages, and …

Primary mitochondrial diseases (PMDs) are associated with pediatric neurological disorders
and are traditionally related to oxidative phosphorylation system (OXPHOS) defects in …