Isoforms of the casein kinase 1 (CK1) family have been shown to phosphorylate key
regulatory molecules involved in cell cycle, transcription and translation, the structure of the …

Members of the highly conserved and ubiquitously expressed pleiotropic CK1 family play
major regulatory roles in many cellular processes including DNA-processing and repair …

Abstract Ras-associated protein-1 (Rap1), a small GTPase in the Ras-related protein family,
is an important regulator of basic cellular functions (eg, formation and control of cell …

The inhibitor of kappa B kinase (IKK) family consists of IKKα, IKKβ, and the IKK-related
kinases TBK1 and IKKε. These kinases are considered master regulators of inflammation …

Casein kinase 1α (CK1α) is a multifunctional protein belonging to the CK1 protein family that
is conserved in eukaryotes from yeast to humans. It regulates signaling pathways related to …

cAMP-dependent pathway is one of the most significant signaling cascades in healthy and
neoplastic ovarian cells. Working through its major effector proteins—PKA and EPAC—it …

Glucocorticoids are widely used in conjunction with chemotherapy for ovarian cancer to
prevent hypersensitivity reactions. Here we reveal a novel role for glucocorticoids in the …

Metastasis is a formidable challenge in the prognosis of melanoma. Accurately predicting
the metastatic potential of non-metastatic melanoma (NMM) and determining effective …

Defining the full complement of substrates for each ubiquitin ligase remains an important
challenge. Improvements in mass spectrometry instrumentation and computation and in …

Cellular proteins are degraded by the ubiquitin-proteasome system (UPS) in a precise and
timely fashion. Such precision is conferred by the high substrate specificity of ubiquitin …