Checkpoint responses to DNA double-strand breaks
DP Waterman, JE Haber… - Annual review of …, 2020 - annualreviews.org
Cells confront DNA damage in every cell cycle. Among the most deleterious types of DNA
damage are DNA double-strand breaks (DSBs), which can cause cell lethality if unrepaired …
damage are DNA double-strand breaks (DSBs), which can cause cell lethality if unrepaired …
The Paf1 complex: a keystone of nuclear regulation operating at the interface of transcription and chromatin
The regulation of transcription by RNA polymerase II is closely intertwined with the
regulation of chromatin structure. A host of proteins required for the disassembly …
regulation of chromatin structure. A host of proteins required for the disassembly …
In‐depth and 3‐dimensional exploration of the budding yeast phosphoproteome
Phosphorylation is one of the most dynamic and widespread post‐translational
modifications regulating virtually every aspect of eukaryotic cell biology. Here, we assemble …
modifications regulating virtually every aspect of eukaryotic cell biology. Here, we assemble …
The DNA damage checkpoint: A tale from budding yeast
P Pizzul, E Casari, M Gnugnoli, C Rinaldi… - Frontiers in …, 2022 - frontiersin.org
Studies performed in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces
pombe have led the way in defining the DNA damage checkpoint and in identifying most of …
pombe have led the way in defining the DNA damage checkpoint and in identifying most of …
A consensus set of genetic vulnerabilities to ATR inhibition
N Hustedt, A Álvarez-Quilón, A McEwan… - Open …, 2019 - royalsocietypublishing.org
The response to DNA replication stress in eukaryotes is under the control of the ataxia–
telangiectasia and Rad3-related (ATR) kinase. ATR responds to single-stranded (ss) DNA to …
telangiectasia and Rad3-related (ATR) kinase. ATR responds to single-stranded (ss) DNA to …
Cell cycle and DNA repair regulation in the damage response: protein phosphatases take over the reins
A Campos, A Clemente-Blanco - International journal of molecular …, 2020 - mdpi.com
Cells are constantly suffering genotoxic stresses that affect the integrity of our genetic
material. Genotoxic insults must be repaired to avoid the loss or inappropriate transmission …
material. Genotoxic insults must be repaired to avoid the loss or inappropriate transmission …
Mec1, INO80, and the PAF1 complex cooperate to limit transcription replication conflicts through RNAPII removal during replication stress
J Poli, CB Gerhold, A Tosi, N Hustedt… - Genes & …, 2016 - genesdev.cshlp.org
Little is known about how cells ensure DNA replication in the face of RNA polymerase II
(RNAPII)-mediated transcription, especially under conditions of replicative stress. Here we …
(RNAPII)-mediated transcription, especially under conditions of replicative stress. Here we …
The INO80 remodeller in transcription, replication and repair
The accessibility of eukaryotic genomes to the action of enzymes involved in transcription,
replication and repair is maintained despite the organization of DNA into nucleosomes. This …
replication and repair is maintained despite the organization of DNA into nucleosomes. This …
PolySUMOylation by Siz2 and Mms21 triggers relocation of DNA breaks to nuclear pores through the Slx5/Slx8 STUbL
C Horigome, DE Bustard, I Marcomini… - Genes & …, 2016 - genesdev.cshlp.org
High-resolution imaging shows that persistent DNA damage in budding yeast localizes in
distinct perinuclear foci for repair. The signals that trigger DNA double-strand break (DSB) …
distinct perinuclear foci for repair. The signals that trigger DNA double-strand break (DSB) …
Phosphoproteomics reveals distinct modes of Mec1/ATR signaling during DNA replication
Summary The Mec1/Tel1 kinases (human ATR/ATM) play numerous roles in the DNA
replication stress response. Despite the multi-functionality of these kinases, studies of their …
replication stress response. Despite the multi-functionality of these kinases, studies of their …