Within a few years after the first successful clinical use of penicillin, investigations were
conducted in animal infection models to explore a range of factors that were considered …

Antibiotic resistance presents an incessant threat to our drug armamentarium that
necessitates novel approaches to therapy. Over the past several decades, investigation of …

Purpose Individualising drug dosing using model-informed precision dosing (MIPD) of beta-
lactam antibiotics and ciprofloxacin has been proposed as an alternative to standard dosing …

模型引导的精准用药(MIPD) 是通过数学建模与模拟技术, 将患者, 药物和疾病等相关信息进行
整合, 为患者精准用药提供依据. 相较于经验用药, MIPD 是一种基于患者生理, 病理, 遗传 …

Background Owing to its low risk of adverse effects, teicoplanin has been extensively used
in patients with infections caused by MRSA. To promote the better management of patients …

Intensive care unit (ICU) patients with end-organ failure will require specialised machines or
extracorporeal therapies to support the failing organs that would otherwise lead to death …

Microneedle (MN) patches, which allow the extraction of skin interstitial fluid (ISF) without a
pain sensation, are powerful tools for minimally invasive biofluid sampling. Herein, an MN …

Background High-dose daptomycin is increasingly used in patients with bone and joint
infection (BJI). This raises concerns about a higher risk of adverse events (AEs), including …

Introduction Estimation of vancomycin area under the curve (AUC) is challenging in the case
of discontinuous administration. Machine learning approaches are increasingly used and …

Purpose Inadequate piperacillin (PIP) exposure in intensive care unit (ICU) patients
threatens therapeutic success. Model-informed precision dosing (MIPD) might be promising …