Mechanisms of key innate immune cells in early-and late-onset preeclampsia

I Aneman, D Pienaar, S Suvakov, TP Simic… - Frontiers in …, 2020 - frontiersin.org
Preeclampsia is a complex cardiovascular disorder of pregnancy with underlying
multifactorial pathogeneses; however, its etiology is not fully understood. It is characterized …

Pathophysiology of preeclampsia

SA Friedman, RN Taylor, JM Roberts - Clinics in perinatology, 1991 - Elsevier
Preeclampsia is a complex clinical syndrome, with hypertension representing but one
manifestation. We propose that pathogenetically important events in the development of …

Eicosanoids in preeclampsia

SW Walsh - Prostaglandins, leukotrienes and essential fatty acids, 2004 - Elsevier
Preeclampsia is characterized by an imbalance between two cyclooxygenase metabolites of
arachidonic acid, thromboxane and prostacyclin, that favors thromboxane. Because of the …

The role of macrophages in utero-placental interactions during normal and pathological pregnancy

SJ Renaud, CH Graham - Immunological investigations, 2008 - Taylor & Francis
The intimate association between maternal and placental tissues elicits an interesting
immunological paradox. Placental tissue contains paternal antigens, but under normal …

Aspirin for the prevention and treatment of pre‐eclampsia: A matter of COX‐1 and/or COX‐2 inhibition?

KM Mirabito Colafella, RI Neuman… - Basic & clinical …, 2020 - Wiley Online Library
Since the 1970s, we have known that aspirin can reduce the risk of pre‐eclampsia.
However, the underlying mechanisms explaining this risk reduction are poorly understood …

Predictive value of CA 125 antigen levels in second-look procedures for ovarian cancer

JM Niloff, RC Bast Jr, EM Schaetzl… - American journal of …, 1985 - Elsevier
Serum CA 125 levels were evaluated in 44 patients undergoing 56 second-look or
subsequent laparoscopies (43) and laparotomies (13) for ovarian cancer. In each patient …

Evidence against the hypothesis that prostaglandins are the vasodepressor agents of pregnancy. Serial studies in chronically instrumented, conscious rats.

KP Conrad, MC Colpoys - The Journal of clinical …, 1986 - Am Soc Clin Investig
Renal hemodynamics increase dramatically during pregnancy, and pressor responsiveness
to exogenous administration of vasoconstrictors is attenuated. We investigated whether or …

Urinary serine proteases and activation of ENaC in kidney—implications for physiological renal salt handling and hypertensive disorders with albuminuria

P Svenningsen, H Andersen, LH Nielsen… - Pflügers Archiv-European …, 2015 - Springer
Serine proteases, both soluble and cell-attached, can activate the epithelial sodium channel
(ENaC) proteolytically through release of a putative 43-mer inhibitory tract from the …

Aldosterone, salt, and potassium intakes as predictors of pregnancy outcome, including preeclampsia

A Birukov, LB Andersen, F Herse, N Rakova… - …, 2019 - Am Heart Assoc
The mineralocorticoid aldosterone increases in plasma in healthy pregnancy along with
renin and angiotensin II and plays a key role in the physiological plasma volume expansion …

Urinary plasmin activates collecting duct ENaC current in preeclampsia

KB Buhl, UG Friis, P Svenningsen… - …, 2012 - Am Heart Assoc
In nephrotic syndrome, plasminogen is aberrantly filtered from plasma to the urinary space
and activated along the tubular system. In vitro, plasmin increases ENaC current by …