Antioxidants in brain tumors: current therapeutic significance and future prospects

X Qi, SK Jha, NK Jha, S Dewanjee, A Dey, R Deka… - Molecular Cancer, 2022 - Springer
Brain cancer is regarded among the deadliest forms of cancer worldwide. The distinct tumor
microenvironment and inherent characteristics of brain tumor cells virtually render them …

Oxidative stress and neurodegeneration in animal models of seizures and epilepsy

K Łukawski, SJ Czuczwar - Antioxidants, 2023 - mdpi.com
Free radicals are generated in the brain, as well as in other organs, and their production is
proportional to the brain activity. Due to its low antioxidant capacity, the brain is particularly …

Seizure‐induced oxidative stress in temporal lobe epilepsy

S Puttachary, S Sharma, S Stark… - BioMed research …, 2015 - Wiley Online Library
An insult to the brain (such as the first seizure) causes excitotoxicity, neuroinflammation, and
production of reactive oxygen/nitrogen species (ROS/RNS). ROS and RNS produced during …

Oxidative stress in epilepsy

U Geronzi, F Lotti, S Grosso - Expert Review of Neurotherapeutics, 2018 - Taylor & Francis
Introduction: The brain is particularly susceptible to oxidative stress being the most
aerobically active organ in the body due to its high metabolic demands. There is evidence …

Mitochondria, oxidative stress, and temporal lobe epilepsy

S Waldbaum, M Patel - Epilepsy research, 2010 - Elsevier
Mitochondrial oxidative stress and dysfunction are contributing factors to various
neurological disorders. Recently, there has been increasing evidence supporting the …

Mitochondrial uncoupling proteins in the CNS: in support of function and survival

ZB Andrews, S Diano, TL Horvath - Nature Reviews Neuroscience, 2005 - nature.com
Mitochondrial uncoupling mediated by uncoupling protein 1 (UCP1) is classically associated
with non-shivering thermogenesis by brown fat. Recent evidence indicates that UCP family …

Apolipoprotein D in oxidative stress and inflammation

G Fyfe-Desmarais, F Desmarais, É Rassart, C Mounier - Antioxidants, 2023 - mdpi.com
Apolipoprotein D (ApoD) is lipocalin able to bind hydrophobic ligands. The APOD gene is
upregulated in a number of pathologies, including Alzheimer's disease, Parkinson's disease …

Mitochondrial dysfunction and oxidative stress: a contributing link to acquired epilepsy?

S Waldbaum, M Patel - Journal of bioenergetics and biomembranes, 2010 - Springer
Mitochondrial dysfunction and oxidative stress contribute to several neurologic disorders
and have recently been implicated in acquired epilepsies such as temporal lobe epilepsy …

Role of selenium on calcium signaling and oxidative stress-induced molecular pathways in epilepsy

M Nazıroğlu - Neurochemical research, 2009 - Springer
Epilepsy is one of the oldest neurological conditions known to humankind. It is known that
oxidative stress and generation of reactive oxygen species are a cause and consequence of …

Role of oxidative stress in metabolic reprogramming of brain cancer

K Agrawal, S Asthana, D Kumar - Cancers, 2023 - mdpi.com
Simple Summary According to Globocan 2020 data, approximately 308,102 new cases of
brain cancer and central nervous system (CNS) cancers were reported worldwide, with …