Chronic kidney disease (CKD) was a major public health problem worldwide. Renal fibrosis,
especially tubulointerstitial fibrosis, is final manifestation of CKD. Many studies have …

Background Given the challenges on diabetic nephropathy (DN) treatment, research has
been carried out progressively focusing on dietary nutrition and natural products as a novel …

The aberrant expression of ubiquitin-specific protease 11 (USP11) is believed to be related
to tumor progression. However, few studies have reported the biological function and clinical …

Macrophages are widely distributed throughout various tissues of the body, and mounting
evidence suggests their involvement in regulating the tissue microenvironment, thereby …

Objectives Diabetic kidney disease (DKD) is a prevalent microvascular complication of
diabetes. Inhibiting the epithelial-mesenchymal transition (EMT) of proximal tubule epithelial …

BACKGROUND Cardiorenal syndrome (CRS)—renal injury during heart failure (HF)—is
linked to high morbidity. Whether circulating extracellular vesicles (EVs) and their RNA …

Abstract p53 is a major regulator of cell cycle arrest, apoptosis, and senescence. While
involvement of p53 in tumorigenesis is well established, recent studies implicate p53 in the …

Abstract Histone deacetylase 3 (HDAC3) plays a crucial role in chromatin remodeling,
which, in turn, regulates gene transcription. Hence, HDAC3 has been implicated in various …

Non-coding RNA has aroused great research interest recently, they play a wide range of
biological functions, such as regulating cell cycle, cell proliferation, and intracellular …

Tubulointerstitial abnormalities contribute to the progression of diabetic kidney disease
(DKD). However, the underlying mechanism of the pathobiology of tubulointerstitial disease …