The RAS/RAF/MEK/ERK (MAPK) signaling cascade is essential for cell inter-and intra-
cellular communication, which regulates fundamental cell functions such as growth, survival …

The extracellular signal-regulated kinase 1/2 (ERK1/2) mitogen-activated protein kinase
(MAPK) signalling pathway regulates many cellular functions, including proliferation …

Molecular target inhibitors have been regularly approved by Food and Drug Administration
(FDA) for tumor treatment, and most of them intervene in tumor cell proliferation and …

Targeted inhibition of oncogenic pathways can be highly effective in halting the rapid growth
of tumors but often leads to the emergence of slowly dividing persister cells, which constitute …

KRAS is the most frequently mutated oncogene. The incidence of specific KRAS alleles
varies between cancers from different sites, but it is unclear whether allelic selection results …

The stabilization of protein–protein interactions (PPIs) has emerged as a promising strategy
in chemical biology and drug discovery. The identification of suitable starting points for …

Purpose: Covalent inhibitors of KRASG12C specifically target tumors driven by this form of
mutant KRAS, yet early studies show that bypass signaling drives adaptive resistance …

Dysregulation of protein–protein interactions (PPIs) commonly leads to disease. PPI
stabilization has only recently been systematically explored for drug discovery despite being …

SOS1 and SOS2 are the most universal and widely expressed family of guanine exchange
factors (GEFs) capable or activating RAS or RAC1 proteins in metazoan cells. SOS proteins …

The RAS-regulated RAF–MEK1/2–ERK1/2 pathway promotes cell proliferation and survival
and RAS and BRAF proteins are commonly mutated in cancer. This has fuelled the …