Fungi are a highly diverse group of heterotrophic eukaryotes characterized by the absence
of phagotrophy and the presence of a chitinous cell wall. While unicellular fungi are far from …

There is no effective cure for Chagas disease, which is caused by infection with the
arthropod-borne parasite, Trypanosoma cruzi. In the search for new drugs to treat Chagas …

Leishmania donovani is the causing agent of visceral leishmaniasis, a common infection
that affects millions of people from the most underdeveloped countries. Miltefosine is the …

Parasitic diseases are still a huge problem for mankind. They are becoming the main cause
of chronic diseases in the world. Migration of the population, pollution of the natural …

Cryptococcosis is an infectious disease of global significance for which new therapies are
needed. Repurposing previously developed drugs for new indications can expedite the …

New, more accessible therapies for cryptococcosis represent an unmet clinical need of
global importance. We took a repurposing approach to identify previously developed drugs …

Chagas disease is a significant health problem in Latin America and the available
treatments have significant issues in terms of toxicity and efficacy. There is thus an urgent …

The Trypanosomatidae family includes the genera Trypanosoma and Leishmania,
protozoan parasites displaying complex digenetic life cycles requiring a vertebrate host and …

Parasitic diseases caused by protozoans are highly prevalent around the world,
disproportionally affecting developing countries, where coinfection with other …

Cell-based screening has become the major compound interrogation strategy in Chagas
disease drug discovery. Several different cell lines have been deployed as host cells in …