Heparanase (HPSE) is an endoglycosidase that catalyses the cutting of the side chains of
heparan-sulphate proteoglycans (HS), thus determining the remodelling of the extracellular …

Heparanase is an endoglycosidase involved in remodeling the extracellular matrix and
thereby in regulating multiple cellular processes and biological activities. It cleaves heparan …

This review summarizes key developments in the heparanase field obtained 20 years prior
to cloning of the HPSE gene and nearly 20 years after its cloning. Of the numerous …

Beyond anticoagulation, the therapeutic potential of heparin derivatives and heparan sulfate
(HS) mimetics (functionally defined HS mimetics) in oncology is related to their ability to bind …

Chronic gastritis caused by Helicobacter pylori (H. pylori) infection has been widely
recognized as the most important risk factor for gastric cancer. Analysis of the interaction …

It is now well recognized that heparanase, an endo-β-D-glucuronidase capable of cleaving
heparan sulfate (HS) side chains at a limited number of sites, promotes tumorigenesis by …

Heparanase (Hpa1) is expressed by tumor cells and cells of the tumor microenvironment
and functions extracellularly to remodel the extracellular matrix (ECM) and regulate the …

The heparan sulfate mimetic PI-88 (muparfostat) is a complex mixture of sulfated
oligosaccharides that was identified in the late 1990s as a potent inhibitor of heparanase. In …

Simple Summary The current treatment options for medulloblastoma, the most common
malignant childhood brain cancer, are associated with many negative side effects and …

Heparanase is an endo‐β‐d‐glucuronidase that cleaves heparan sulfate (HS) side chains of
heparan sulfate proteoglycans. Compelling evidence tie heparanase levels with all steps of …