The functions, purposes, and roles of metallothioneins have been the subject of
speculations since the discovery of the protein over 60 years ago. This article guides …

The potent redox activity of copper is required for sustaining life. Mismanagement of its
cellular pools, however, can result in oxidative stress and damage connected to aging …

The solution and complexation chemistry of zinc ions is the basis for zinc biology. In living
organisms, zinc is redox-inert and has only one valence state: Zn (II). Its coordination …

The rate of consumption of dithiothreitol (DTT) is increasingly used to measure the oxidative
potential of particulate matter (PM), which has been linked to the adverse health effects of …

Copper is an essential trace element for eukaryotes and most prokaryotes. However,
intracellular free copper must be strictly limited because of its toxic side effects. Complex …

Essential metal ions are tightly controlled in biological systems. An understanding of metal
metabolism and homeostasis is being developed from quantitative information of the sizes …

The contamination of drinking water with arsenic poses a threat to global health.[1a–e] As
many as 140 million people worldwide may have been exposed to drinking water with …

Particulate matter (PM)-mediated reactive oxygen species (ROS) generation has been
implicated in health effects posed by PM. Humic-like substances (HULIS) are an unresolved …

Literature estimates of metal-protein affinities are widely scattered for many systems, as
highlighted by the class of metallo-chaperone proteins, which includes human Atox1. The …

Redox-active species in ambient particulate matter (PM) cause adverse health effects
through the production of reactive oxygen species (ROS) in the human respiratory tract …