Selenium drives a transcriptional adaptive program to block ferroptosis and treat stroke

I Alim, JT Caulfield, Y Chen, V Swarup, DH Geschwind… - Cell, 2019 - cell.com
Ferroptosis, a non-apoptotic form of programmed cell death, is triggered by oxidative stress
in cancer, heat stress in plants, and hemorrhagic stroke. A homeostatic transcriptional …

The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancer

MRD Improgo, MD Scofield, AR Tapper… - Progress in …, 2010 - Elsevier
More than 1 billion people around the world smoke, with 10 million cigarettes sold every
minute. Cigarettes contain thousands of harmful chemicals including the psychoactive …

Why so many forms of acetylcholinesterase?

C Legay - Microscopy research and technique, 2000 - Wiley Online Library
Acetylcholinesterase is a key molecule in the control of cholinergic transmission. In the
mammalian neuromuscular junction (NMJ), the efficiency of this phenomenon depends on …

Evidence for multiple alleles at the DGAT1 locus better explains a quantitative trait locus with major effect on milk fat content in cattle

C Kühn, G Thaller, A Winter, ORP Bininda-Emonds… - Genetics, 2004 - academic.oup.com
A quantitative trait locus (QTL) for milk fat percentage has been mapped consistently to the
centromeric region of bovine chromosome 14 (BTA14). Two independent studies have …

Acetylcholinesterase in Hirschsprung's disease

SW Moore, G Johnson - Pediatric surgery international, 2005 - Springer
The association between the congenital absence of colonic ganglion cells and an increased
acetylcholinesterase (AChE) expression in the affected tissue is of diagnostic importance in …

Nicotinic acetylcholine receptors of adrenal chromaffin cells

F Sala, A Nistri, M Criado - Acta physiologica, 2008 - Wiley Online Library
In the adrenal medulla, acetylcholine released by the sympathetic splanchnic nerves
activates neuronal‐type nicotinic acetylcholine receptors (nAChRs) on the membrane of …

From smoking to lung cancer: the CHRNA5/A3/B4 connection

MRD Improgo, MD Scofield, AR Tapper, PD Gardner - Oncogene, 2010 - nature.com
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that modulate key
physiological processes ranging from neurotransmission to cancer signaling. These …

Tau promoter confers neuronal specificity and binds Sp1 and AP‐2

A Heicklen‐Klein, I Ginzburg - Journal of neurochemistry, 2000 - Wiley Online Library
Tau, a microtubule‐associated protein, is encoded by a single gene, whose expression is
primarily neuronal. In this work, we defined an 80‐bp region of the tau promoter that confers …

Sp1 and Sp3 regulate expression of the neuronal nicotinic acetylcholine receptor β4 subunit gene

CB Bigger, IN Melnikova, PD Gardner - Journal of Biological Chemistry, 1997 - ASBMB
Neuronal nicotinic acetylcholine receptors play important roles in signal transduction within
the nervous system. The receptors exist in a variety of functionally distinct subtypes that are …

[HTML][HTML] Transcription factor repression and activation of the human acetylcholinesterase gene

DK Getman, A Mutero, K Inoue, P Taylor - Journal of Biological Chemistry, 1995 - Elsevier
Acetylcholinesterase in man is encoded by a single gene, ACHE, located on chromosome
7q22. In this study, the transcription start sites and major DNA promoter elements controlling …