Abstract MicroRNA-34 (miR-34) has been reported to be dysregulated in various human
cancers and regarded as a tumor suppressive microRNA because of its synergistic effect …

Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. One of the
fundamental processes driving the initiation and progression of CRC is the accumulation of …

Curcumin, a natural phytochemical isolated from tumeric roots, represents a candidate for
prevention and therapy of colorectal cancer/CRC. However, the exact mechanism of action …

Epithelial to mesenchymal transition (EMT) is essential for driving plasticity during
development, but is an unintentional behaviour of cells during cancer progression. The EMT …

Epithelial–mesenchymal transition (EMT) is a key step in transdifferentiation process in solid
cancer development. Forthcoming evidence suggest that the stratified program transforms …

Genotoxic colibactin-producing pks+ Escherichia coli induce DNA double-strand breaks,
mutations, and promote tumor development in mouse models of colorectal cancer (CRC) …

MicroRNAs (miRNAs) are short non-coding RNAs that act as important regulators of gene
expression as part of the epigenetic machinery. In addition to posttranscriptional gene …

MicroRNA miR-34a is recognized as a master regulator of tumor suppression. The strategy
of miR-34a replacement has been investigated in clinical trials as the first attempt of miRNA …

The miR-34a and miR-34b/c encoding genes represent direct targets of the p53 transcription
factor, and presumably mediate part of the tumor suppressive effects of p53. Here, we …

MicroRNA-34 (miR-34) is a master regulator of tumor suppression. It is downregulated in
numerous cancers and inhibits malignant growth by repressing genes involved in various …