Major depressive disorder (MDD) will affect one out of every five people in their lifetime and
is the leading cause of disability worldwide. Nevertheless, mechanisms associated with the …

Symptoms of cognitive dysfunction like memory loss, poor concentration, impaired learning
and executive functions are characteristic features of both schizophrenia and Alzheimer's …

The neurotransmitter serotonin (5-hdroxytryptamine; 5-HT) has been implicated in the
pathophysiology and treatment of major depression since the serendipitous discovery of …

Stress can have a lasting impact on the structure and function of brain circuitry that results in
long-lasting changes in the behavior of an organism. Synaptic plasticity is the mechanism by …

Depression induces structural and functional synaptic plasticity in brain reward circuits,
although the mechanisms promoting these changes and their relevance to behavioral …

Serotonin modulates several physiological and cognitive pathways throughout the human
body that affect emotions, memory, sleep, and thermal regulation. The complex nature of the …

Purpose: Depression is one of the most prevalent, recurrent and life-threatening mental
illnesses. However, the precise mechanism underlying the disorder is not yet clearly …

The monoamine hypothesis of depression posits that an imbalance in monoaminergic
neurotransmission is causally related to the clinical features of depression. Antidepressants …

Abstract Behavioral and Psychological Symptoms of Dementia (BPSD), present in almost
90% of patients with Alzheimer's Disease (AD), cause extensive impairment leading to …

Integration of physiologically relevant in vitro assays at the earliest stages of drug discovery
may improve the likelihood of successfully translating preclinical discoveries to the clinic …