Having a hypoxic microenvironment is a common and salient feature of most solid tumors.
Hypoxia has a profound effect on the biological behavior and malignant phenotype of …

Immune checkpoint blockade therapy targeting programmed cell death protein 1 (PD-1) has
revolutionized the landscape of multiple human cancer types, including head and neck …

Despite recent advances, the poor outcomes in renal cell carcinoma (RCC) suggest novel
therapeutics are needed. Ferroptosis is a form of regulated cell death, which may have …

The PEA3 subfamily is a subgroup of the E26 transformation-specific (ETS) family. Its
members, ETV1, ETV4, and ETV5, have been found to be overexpressed in multiple …

Cancers have an altered metabolism, and there is interest in understanding precisely how
oncogenic transformation alters cellular metabolism and how these metabolic alterations …

All organisms exposed to metabolic and environmental stresses have developed various
stress adaptive strategies to maintain homeostasis. The main bacterial stress survival …

O‐Glc NA cylation is an essential, nutrient‐sensitive post‐translational modification, but its
biochemical and phenotypic effects remain incompletely understood. To address this …

Chronic or non-communicable diseases are the leading cause of death worldwide; they
usually result in long-term illnesses and demand long-term care. Despite advances in …

Ferroptosis is a novel form of iron-dependent cell death characterized by lipid peroxidation.
While the importance and disease relevance of ferroptosis is gaining recognition, much …

Oncogenic transformation may reprogram tumor metabolism and render cancer cells
addicted to extracellular nutrients. Deprivation of these nutrients may therefore represent a …