Mechanisms of regulation of the chemokine-receptor network

MJ Stone, JA Hayward, C Huang, Z E. Huma… - International journal of …, 2017 - mdpi.com
The interactions of chemokines with their G protein-coupled receptors promote the migration
of leukocytes during normal immune function and as a key aspect of the inflammatory …

Function, diversity and therapeutic potential of the N-terminal domain of human chemokine receptors

M Szpakowska, V Fievez, K Arumugan… - Biochemical …, 2012 - Elsevier
Chemokines and their receptors play fundamental roles in many physiological and
pathological processes such as leukocyte trafficking, inflammation, cancer and HIV-1 …

The dimeric form of CXCL12 binds to atypical chemokine receptor 1

JC Gutjahr, KS Crawford, DR Jensen, P Naik… - Science …, 2021 - science.org
The pleiotropic chemokine CXCL12 is involved in diverse physiological and
pathophysiological processes, including embryogenesis, hematopoiesis, leukocyte …

Duffy antigen receptor for chemokines and its involvement in patterning and control of inflammatory chemokines

I Novitzky-Basso, A Rot - Frontiers in immunology, 2012 - frontiersin.org
Leukocyte functions are linked to their migratory responses, which, in turn, are largely
determined by the expression profile of classical chemokine receptors. Upon binding their …

How post-translational modifications influence the biological activity of chemokines

V Vanheule, M Metzemaekers, R Janssens, S Struyf… - Cytokine, 2018 - Elsevier
Chemokines are important proteins involved in the regulation of directed leukocyte migration
during inflammation and the homeostatic homing of immune cells. In addition, they play a …

Glycosylation of blood cells during the onset and progression of atherosclerosis and myocardial infarction

F Ferro, R Spelat, A Pandit, JL Martin-Ventura… - Trends in Molecular …, 2024 - cell.com
Protein glycosylation controls cell–cell and cell–extracellular matrix (ECM) communication in
immune, vascular, and inflammatory processes, underlining the critical role of this process in …

Glycobiology of leukocyte trafficking in inflammation

RD Wright, D Cooper - Glycobiology, 2014 - academic.oup.com
To fulfill their potential, leukocytes must be able to exit the vasculature and reach the site of
inflammation within the tissue. This process of leukocyte extravasation is a tightly regulated …

A recombinant dromedary antibody fragment (VHH or nanobody) directed against human Duffy antigen receptor for chemokines

D Smolarek, C Hattab… - Cellular and Molecular …, 2010 - Springer
Fy blood group antigens are carried by the Duffy antigen receptor for chemokines (DARC), a
red cells receptor for Plasmodium vivax broadly implicated in human health and diseases …

A single point mutation in the gene encoding Gb3/CD77 synthase causes a rare inherited polyagglutination syndrome

A Suchanowska, R Kaczmarek, M Duk… - Journal of Biological …, 2012 - ASBMB
Rare polyagglutinable NOR erythrocytes contain three unique globoside (Gb4Cer)
derivatives, NOR1, NOR int, and NOR2, in which Gal (α1–4), GalNAc (β1–3) Gal (α1–4), and …

Structural Space of the Duffy Antigen/Receptor for Chemokines' Intrinsically Disordered Ectodomain 1 Explored by Temperature Replica-Exchange Molecular …

A Kranjc, TJ Narwani, SS Abby… - International Journal of …, 2023 - mdpi.com
Plasmodium vivax malaria affects 14 million people each year. Its invasion requires
interactions between the parasitic Duffy-binding protein (Pv DBP) and the N-terminal …