Broad interest in developing new hemostatic technologies arises from unmet needs in
mitigating uncontrolled hemorrhage in emergency, surgical, and battlefield settings …

Mitochondria are a major target in hypoxic/ischemic injury. Mitochondrial impairment
increases with age leading to dysregulation of molecular pathways linked to mitochondria …

BACKGROUND: The clinical use of frozen plasma (FP) continues to increase, both in
prophylactic and in therapeutic settings. In 2004, a systematic review of all published …

Background Ultrasonography (performed by means of a four‐quadrant, focused assessment
of sonography for trauma (FAST)) is regarded as a key instrument for the initial assessment …

Abstract Background Low fibrinogen (Fg) concentrations in trauma haemorrhage are
associated with poorer outcomes. Cryoprecipitate is the standard source for Fg …

Trauma-induced coagulopathy is associated with very high mortality, and hemorrhage
remains the leading preventable cause of death after injury. Directed methods to combat …

Hemostatic powders provide an important treatment approach for time-sensitive hemorrhage
control. Conventional hemostatic powders are challenged by the lack of tissue …

Abstract In June 2011 the Canadian National Advisory Committee on Blood and Blood
Products sponsored an international consensus conference on transfusion and trauma. A …

Abstract In the United States, trauma claims the lives of over 150,000 civilians each year. In
military settings, trauma and exsanguination result in 50% of combat related deaths. The …

Aging is characterized by increased oxidative stress, heightened inflammatory response,
accelerated cellular senescence and progressive organ dysfunction. The homeostatic …