Biophysical considerations for development of antibody-based therapeutics

AW Drake, YN Abdiche, GA Papalia - Development of Antibody-Based …, 2018 - Springer
Abstract Development of therapeutic monoclonal antibodies requires rigorous
measurements of the kinetic and thermodynamic binding properties of antibody–antigen …

Considerations for construct and affinity design goals

MA Tabrizi, SL Klakamp - Development of Antibody-Based Therapeutics …, 2018 - Springer
Application of an integrated approach for inclusion of pharmacology principles in drug
development is a foundational step for effective modality design and selection of antibody …

Translational Considerations and Challenges: An Overview

V Ganti, MA Tabrizi - Development of Antibody-Based Therapeutics …, 2018 - Springer
Biologics are one of the fastest growing subsets of pharmaceuticals today. In 2016, ten
monoclonal antibodies were approved by the FDA for diverse conditions such as psoriasis …