Emerging as an epidemic of the 21st century type 2 diabetes has become a major health
problem throughout the globe. The number of deaths attributable to diabetes reflects the …

Although boronic acids have attracted considerable interest as versatile intermediates in
organic synthesis, their contributions in chemical biology and drug discovery programs have …

Membrane-bound proteases have recently emerged as critical mediators of tumorigenesis,
angiogenesis, and metastasis. However, the mechanisms by which they regulate these …

Fibroblast activation protein (FAP) is a serine protease that is generally accepted to play an
important role in tumor growth and other diseases involving tissue remodeling. Currently …

Fibroblast activation protein (FAP) is a non-classical serine protease expressed
predominantly in conditions accompanied by tissue remodeling, particularly cancer. Due to …

Fibroblast activation protein (FAP) is a transmembrane serine peptidase that belongs to the
prolyl peptidase family. FAP has been implicated in cancer; however, its specific role …

US9155705B2 - DPP-IV inhibitor combined with a further antidiabetic agent, tablets
comprising such formulations, their use and process for their preparation - Google Patents …

Fibroblast activation protein (FAP) has become a favored target for imaging and therapy of
malignancy. We have synthesized and characterized two new (4-quinolinoyl)-glycyl-2 …

The speci? cation describes the use of selected DPP IV inhibi tors for the treatment of
physiological functional disorders and for reducing the risk of the occurrence of such …

Objective Since fibroblasts in the synovium of patients with rheumatoid arthritis (RA) express
the serine proteases fibroblast activation protein (FAP) and dipeptidylpeptidase 4 (DPP …