The fields of theoretical and computational chemistry have come a long way since their
inception in the mid-20th century. Fifty years ago, only rudimentary approximations for very …

Inteins are nature's escape artists; they facilitate their excision from flanking polypeptides
(exteins) concomitant with extein ligation to produce a mature host protein. Splicing requires …

Revised and updated, Chemical Reagents for Protein Modification, Third Edition is an
encyclopedic work describing the many approaches to the site-specific modification of …

Protein trans-splicing (PTS) by split inteins has found widespread use in chemical biology
and biotechnology. Herein, we describe the use of a consensus design approach to …

S-to-N acyl transfer is a high-yielding chemoselective process for amide bond formation. It is
widely utilized by chemists for synthetic applications, including peptide and protein …

Inteins catalyze a post-translational modification known as protein splicing, where the intein
removes itself from a precursor protein and concomitantly ligates the flanking protein …

Inteins are mobile genetic elements that apply standard enzymatic strategies to excise
themselves post-translationally from the precursor protein via protein splicing. Since their …

The p K a values of a series of chiral Brønsted acids, including N-triflylphosphoramides, bis
(sulfonyl) imides, bis (sulfuryl) imides, dicarboxylic acids, sulfonic acids, and N-phosphinyl …

Peptide and protein thioesters are playing an increasingly prominent role in the chemical
toolbox for protein assembly and modification through Native Chemical Ligation (NCL). In …

Intein enzymes catalyze the splicing of their flanking polypeptide chains and have found
tremendous biotechnological applications. Their terminal residues form the catalytic core …