Cell division orientation during animal development can serve to correctly organize and
shape tissues, create cellular diversity or both. The underlying cellular mechanism is …

During the first cell-fate decision of mouse preimplantation embryo development, a
population of outer-residing polar cells is segregated from a second population of inner …

Planar cell polarity (PCP) proteins form polarized cortical domains that govern polarity of
external structures such as hairs and cilia in both vertebrate and invertebrate epithelia. The …

Orientation of cell divisions is a key mechanism of tissue morphogenesis. In the growing
Drosophila wing imaginal disc epithelium, most of the cell divisions in the central wing …

The spatial organization of cells depends on their ability to sense their own shape and size.
Here, we investigate how cell shape affects the positioning of the nucleus, spindle and …

The division of eukaryotic cells involves the assembly of complex cytoskeletal structures to
exert the forces required for chromosome segregation and cytokinesis. In plants, empirical …

For nearly 150 years, it has been recognized that cell shape strongly influences the
orientation of the mitotic cleavage plane (eg, Hofmeister, 1863). However, we still …

Size specification of macromolecular assemblies in the cytoplasm is poorly understood [1].
In principle, assemblies could scale with cell size or use intrinsic mechanisms. For the …

During mammalian development, the first asymmetric cell divisions segregate cells into
inner and outer positions of the embryo to establish the pluripotent and trophectoderm …

The tight junction (TJ) is an essential component of the differentiated epithelial cell required
for polarised transport and intercellular integrity and signalling. Whilst much can be learnt …