Inhibition of Astrocytic Histamine N-Methyltransferase as a Possible Target for the Treatment of Alzheimer's Disease
C Flores-Clemente, MI Nicolás-Vázquez… - Biomolecules, 2021 - mdpi.com
Alzheimer's disease (AD) represents the principal cause of dementia among the elderly.
Great efforts have been established to understand the physiopathology of AD. Changes in …
Great efforts have been established to understand the physiopathology of AD. Changes in …
Interaction of α-cyperone with human serum albumin: Determination of the binding site by using Discovery Studio and via spectroscopic methods
Q Wang, J He, D Wu, J Wang, J Yan, H Li - Journal of Luminescence, 2015 - Elsevier
Abstract α-Cyperone, as the main constituent of Cyperus rotundus, is a sesquiterpene
ketone. In this work, LigandFit and CDOCKER docking programs of Discovery Studio 3.1 …
ketone. In this work, LigandFit and CDOCKER docking programs of Discovery Studio 3.1 …
Identification of New Human Malaria Parasite Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors by Pharmacophore and Structure-Based Virtual …
E Pavadai, F El Mazouni, S Wittlin… - Journal of chemical …, 2016 - ACS Publications
Plasmodium falciparum dihydroorotate dehydrogenase (Pf DHODH), a key enzyme in the de
novo pyrimidine biosynthesis pathway, which the Plasmodium falciparum relies on …
novo pyrimidine biosynthesis pathway, which the Plasmodium falciparum relies on …
[HTML][HTML] Pharmacophore modeling, virtual screening, and molecular docking studies for discovery of novel Akt2 inhibitors
J Fei, L Zhou, T Liu, XY Tang - International journal of medical …, 2013 - ncbi.nlm.nih.gov
Akt2 is considered as a potential target for cancer therapy. In order to find novel Akt2
inhibitors which have different scaffolds, structure-based pharmacophore model and 3D …
inhibitors which have different scaffolds, structure-based pharmacophore model and 3D …
[图书][B] Chemometrics applications and research: QSAR in medicinal chemistry
AG Mercader, PR Duchowicz, PM Sivakumar - 2016 - books.google.com
This important new book provides innovative material, including peer-reviewed chapters
and survey articles on new applied research and development, in the scientifically important …
and survey articles on new applied research and development, in the scientifically important …
Docking simulations and spectroscopy of the interactions of ellagic acid and oleuropein with human serum albumin
The primary objective of this study is to evaluate the interactions of ellagic acid (EA) and
oleuropein (OLE) with human serum albumin (HSA). Plasma protein binding model …
oleuropein (OLE) with human serum albumin (HSA). Plasma protein binding model …
Discovery of novel and highly potential inhibitors of glycogen synthase kinase 3-beta (GSK-3β) through structure-based pharmacophore modeling, virtual …
S Benghanem, F Mesli, HA Fatima Zohra… - Journal of …, 2024 - Taylor & Francis
Abstract The protein Glycogen Synthase Kinase 3-Beta (GSK-3β), is a promising therapeutic
target for treating various diseases such as neurodegenerative disorders, diabetes …
target for treating various diseases such as neurodegenerative disorders, diabetes …
Biological Activity of Sporolides A and B from Salinispora tropica: in silico Target Prediction Using Ligand‐Based Pharmacophore Mapping and in vitro activity …
K Dineshkumar, V Aparna, KZ Madhuri… - Chemical biology & …, 2014 - Wiley Online Library
Sporolides A and B are novel polycyclic macrolides from the obligate marine actinomycetes,
Salinispora tropica. The unique and novel structure of sporolides makes them interesting …
Salinispora tropica. The unique and novel structure of sporolides makes them interesting …
Identification of molecular descriptors for design of novel Isoalloxazine derivatives as potential Acetylcholinesterase inhibitors against Alzheimer's disease
In Alzheimer's disease (AD), the level of Acetylcholine (ACh) neurotransmitter is reduced.
Since Acetylcholinesterase (AChE) cleaves ACh, inhibitors of AChE are very much sought …
Since Acetylcholinesterase (AChE) cleaves ACh, inhibitors of AChE are very much sought …
Design and development of novel inhibitors of aldo-ketoreductase 1C1 as potential lead molecules in treatment of breast cancer
Abstract Aldo–keto reductase 1C1 (AKR1C1) is a hydroxysteroid dehydrogenase, known to
inactivate the biologically active progesterone into its corresponding 20 α …
inactivate the biologically active progesterone into its corresponding 20 α …