CD38: an immunomodulatory molecule in inflammation and autoimmunity

ZL Piedra-Quintero, Z Wilson, P Nava… - Frontiers in …, 2020 - frontiersin.org
CD38 is a molecule that can act as an enzyme, with NAD-depleting and intracellular
signaling activity, or as a receptor with adhesive functions. CD38 can be found expressed …

Monoclonal antibodies targeting CD 38 in hematological malignancies and beyond

NWCJ Van De Donk, ML Janmaat, T Mutis… - Immunological …, 2016 - Wiley Online Library
CD 38 is a multifunctional cell surface protein that has receptor as well as enzyme functions.
The protein is generally expressed at low levels on various hematological and solid tissues …

Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology

F Malavasi, S Deaglio, A Funaro… - Physiological …, 2008 - journals.physiology.org
The membrane proteins CD38 and CD157 belong to an evolutionarily conserved family of
enzymes that play crucial roles in human physiology. Expressed in distinct patterns in most …

CD38 and CD157: a long journey from activation markers to multifunctional molecules

V Quarona, G Zaccarello, A Chillemi… - Cytometry Part B …, 2013 - Wiley Online Library
CD38 (also known as T10) was identified in the late 1970s in the course of pioneering work
carried out at the Dana‐Farber Cancer Center (Boston, MA) that focused on the identification …

CD38 expression as an important prognostic factor in B-cell chronic lymphocytic leukemia

S Ibrahim, M Keating, KA Do, S O'Brien… - Blood, The Journal …, 2001 - ashpublications.org
CD38 is a transmembrane glycoprotein expressed on the surface of leukemic cells in a
significant percentage of patients with B-cell chronic lymphocytic leukemia (B-CLL). A recent …

Human CD38: a (r) evolutionary story of enzymes and receptors

S Deaglio, K Mehta, F Malavasi - Leukemia research, 2001 - Elsevier
Human CD38 is the mammalian prototype of a family of proteins which share structural
similarities and an ectoenzymatic activity involved in the production of calcium mobilizing …

Ectonucleotidases as regulators of purinergic signaling in thrombosis, inflammation, and immunity

S Deaglio, SC Robson - Advances in pharmacology, 2011 - Elsevier
Evolving studies in models of transplant rejection, inflammatory bowel disease, and cancer,
among others, have implicated purinergic signaling in clinical manifestations of vascular …

Anatomy and nomenclature of murine lymph nodes: Descriptive study and nomenclatory standardization in BALB/cAnNCrl mice

W Van den Broeck, A Derore, P Simoens - Journal of immunological …, 2006 - Elsevier
Murine lymph nodes are intensively studied but often assigned incorrectly in scientific
papers. In BALB/cAnNCrl mice, we characterized a total of 22 different lymph nodes …

CD38 and CD100 lead a network of surface receptors relaying positive signals for B-CLL growth and survival

S Deaglio, T Vaisitti, L Bergui, L Bonello, AL Horenstein… - Blood, 2005 - ashpublications.org
This work addresses the question whether CD38, a negative prognostic marker in B-cell
chronic lymphocytic leukemia (B-CLL), plays a role in neoplastic B-cell growth and survival …

CD38, a receptor with multifunctional activities: from modulatory functions on regulatory cell subsets and extracellular vesicles, to a target for therapeutic strategies

F Morandi, I Airoldi, D Marimpietri, C Bracci, AC Faini… - Cells, 2019 - mdpi.com
CD38 is a multifunctional cell surface protein endowed with receptor/enzymatic functions.
The protein is generally expressed at low/intermediate levels on hematological tissues and …