Pathology and pathobiology of pulmonary hypertension: current insights and future directions
In recent years, major advances have been made in the understanding of the cellular and
molecular mechanisms driving pulmonary vascular remodelling in various forms of …
molecular mechanisms driving pulmonary vascular remodelling in various forms of …
Pulmonary hypertension: a contemporary review
S Johnson, N Sommer, K Cox-Flaherty… - American journal of …, 2023 - atsjournals.org
Major advances in pulmonary arterial hypertension, pulmonary hypertension (PH)
associated with lung disease, and chronic thromboembolic PH cast new light on the …
associated with lung disease, and chronic thromboembolic PH cast new light on the …
Digital spatial profiling identifies distinct molecular signatures of vascular lesions in pulmonary arterial hypertension
RM Tuder, A Gandjeva, S Williams… - American Journal of …, 2024 - atsjournals.org
Rationale: Idiopathic pulmonary arterial hypertension (IPAH) is characterized by extensive
pulmonary vascular remodeling caused by plexiform and obliterative lesions, media …
pulmonary vascular remodeling caused by plexiform and obliterative lesions, media …
ATP citrate lyase drives vascular remodeling in systemic and pulmonary vascular diseases through metabolic and epigenetic changes
Y Grobs, C Romanet, SE Lemay, A Bourgeois… - Science Translational …, 2024 - science.org
ATP citrate lyase (ACLY), a crucial enzyme in de novo lipid synthesis and histone
acetylation, plays a key role in regulating vascular smooth muscle cell (VSMC) proliferation …
acetylation, plays a key role in regulating vascular smooth muscle cell (VSMC) proliferation …
Unraveling the epigenetic landscape of pulmonary arterial hypertension: implications for personalized medicine development
Pulmonary arterial hypertension (PAH) is a multifactorial disease associated with the
remodeling of pulmonary blood vessels. If left unaddressed, PAH can lead to right heart …
remodeling of pulmonary blood vessels. If left unaddressed, PAH can lead to right heart …
Environmental exposures influence multigenerational epigenetic transmission
E Klibaner-Schiff, EM Simonin, CA Akdis, A Cheong… - Clinical …, 2024 - Springer
Epigenetic modifications control gene expression and are essential for turning genes on and
off to regulate and maintain differentiated cell types. Epigenetics are also modified by a …
off to regulate and maintain differentiated cell types. Epigenetics are also modified by a …
Restoration of Foxp3+ Regulatory T Cells by HDAC-Dependent Epigenetic Modulation Plays a Pivotal Role in Resolving Pulmonary Arterial Hypertension Pathology
Rationale: Immune dysregulation is a common feature of pulmonary arterial hypertension
(PAH). Histone deacetylase (HDAC)-dependent transcriptional reprogramming …
(PAH). Histone deacetylase (HDAC)-dependent transcriptional reprogramming …
GLI1+ Cells Contribute to Vascular Remodeling in Pulmonary Hypertension
X Chu, V Kheirollahi, A Lingampally… - Circulation …, 2024 - Am Heart Assoc
BACKGROUND: The precise origin of newly formed ACTA2+ (alpha smooth muscle actin-
positive) cells appearing in nonmuscularized vessels in the context of pulmonary …
positive) cells appearing in nonmuscularized vessels in the context of pulmonary …
Switch-independent 3A: an epigenetic regulator in cancer with new implications for pulmonary arterial hypertension
K Jankowski, V Jagana, M Bisserier, L Hadri - Biomedicines, 2023 - mdpi.com
Epigenetic mechanisms, including DNA methylation, histone modifications, and non-coding
RNA, play a crucial role in the regulation of gene expression and are pivotal in biological …
RNA, play a crucial role in the regulation of gene expression and are pivotal in biological …
Molecular Function and Contribution of TBX4 in Development and Disease
JA Karolak, CL Welch, C Mosimann… - American journal of …, 2023 - atsjournals.org
Over the past decade, recognition of the profound impact of the TBX4 (T-box 4) gene, which
encodes a member of the evolutionarily conserved family of T-box–containing transcription …
encodes a member of the evolutionarily conserved family of T-box–containing transcription …