In the 12 years since the publication of the first Consensus Paper of the WFSBP on
biomarkers of neurodegenerative dementias, enormous advancement has taken place in …

Epigenetics has long been recognized as a significant field in biology and is defined as the
investigation of any alteration in gene expression patterns that is not attributed to changes in …

Late-onset Alzheimer's disease is a prevalent age-related polygenic disease that accounts
for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying …

The epidemiological correlation between copper exposure and higher risk of Parkinson
disease (PD) has been recognized for a long time, and microglia-mediated …

Abstract The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide
association study of late-onset Alzheimer disease using a three-stage design consisting of a …

The risk of acquiring a chronic disease is influenced by a person's genetics (G) and
exposures received during life (the 'exposome', E) plus their interactions (G× E). Yet …

An individual's genetic makeup plays a large role in determining susceptibility to Alzheimer's
disease (AD) but has largely been ignored in preclinical studies. To test the hypothesis that …

Context Twin studies using selected samples have shown high heritability for Alzheimer
disease (AD). Objective To evaluate genetic and environmental influences on AD in a fully …

Importance Genetic variants associated with susceptibility to late-onset Alzheimer disease
are known for individuals of European ancestry, but whether the same or different variants …

Single nucleotide polymorphisms (SNPs) are an abundant form of genome variation,
distinguished from rare variations by a requirement for the least abundant allele to have a …