A critical review on recent trends on pharmacological applications of pyrazolone endowed derivatives

G Mustafa, M Zia-ur-Rehman, SH Sumrra… - Journal of Molecular …, 2022 - Elsevier
Pyrazolone is a well-known influential synthon for the synthesis of many molecules which
hold remarkable potential in the advancement of functional materials, coordination …

Insights into the structure activity relationship of nitrogen-containing heterocyclics for the development of antidepressant compounds: An updated review

K Singh, R Pal, SA Khan, B Kumar, MJ Akhtar - Journal of Molecular …, 2021 - Elsevier
Abstract According to the World Health Organization (WHO), depression is a common
mental disorder and includes complex interaction between social and psychological …

An overview of the biological evaluation of selected nitrogen-containing heterocycle medicinal chemistry compounds

O Ebenezer, MA Jordaan, G Carena, T Bono… - International Journal of …, 2022 - mdpi.com
Heterocyclic compounds are a class of compounds of natural origin with favorable
properties and hence have major pharmaceutical significance. They have an exceptional …

[HTML][HTML] Novel pyrazolo [3, 4-d] pyrimidines as potential anticancer agents: Synthesis, VEGFR-2 inhibition, and mechanisms of action

Z Ruzi, K Bozorov, L Nie, J Zhao, HA Aisa - Biomedicine & …, 2022 - Elsevier
Novel pyrazolo[3,4-d]pyrimidines as potential anticancer agents: Synthesis, VEGFR-2 inhibition,
and mechanisms of action - ScienceDirect Skip to main contentSkip to article Elsevier logo …

Nitrogen-containing heterocyclic drug products approved by the FDA in 2023: Synthesis and biological activity

W Luo, Y Liu, H Qin, Z Zhao, S Wang, W He… - European Journal of …, 2024 - Elsevier
This article profiles 13 newly approved nitrogen-containing heterocyclic drugs by the US
Food and Drug Administration (FDA) in 2023. These drugs target a variety of therapeutic …

[HTML][HTML] Thiosemicarbazone derivatives of transition metals as multi-target drugs: a review

S Gupta, N Singh, T Khan, S Joshi - Results in Chemistry, 2022 - Elsevier
The mutations of bacteria and viruses along with the resistance of various targets to the
existing drugs have emerged as great challenges in the medical field. This imposes the …

A decade of synthesis of N-heterocyclic derivatives via magnetically retrievable Fe3O4@SiO2@Cu(II) nanocatalysts: A review (2013-present)

A Soni, P Kumar, V Tomar, RK Joshi… - Synthetic …, 2023 - Taylor & Francis
Medicinal chemistry and synthetic organic chemistry rely primarily on CN bonds for their
structures because a variety of biologically active compounds, including natural products …

Design, synthesis and evaluation of piperazine clubbed 1, 2, 4-triazine derivatives as potent anticonvulsant agents

R Pal, MJ Akhtar, K Raj, S Singh, P Sharma… - Journal of Molecular …, 2022 - Elsevier
The new series of N-(5, 6-diphenyl-1, 2, 4-triazin-3-yl)-2-(4-substituted piperazin-1-yl)
acetamide (RP1–5) and 2-((5, 6-diphenyl-1, 2, 4-triazin-3-yl) thio)-1-(4-substituted piperazin …

Synthesis and antitumor evaluation of some new thiazolopyridine, nicotinonitrile, pyrazolopyridine, and polyhydroquinoline derivatives using ceric ammonium nitrate …

RR Raslan, SA Hessein, SA Fouad… - Journal of …, 2022 - Wiley Online Library
A novel series of thiazolo [5, 4‐b] pyridine, polysubstituted pyridines, pyrazolo [3, 4‐b]
pyridine‐5‐carbonitriles, and polyhydroquinoline were synthesized via one‐pot reaction of 2 …

Schiff Bases: A Captivating Scaffold with Potential Anticonvulsant Activity

R Sahu, K Shah - Mini Reviews in Medicinal Chemistry, 2024 - benthamdirect.com
One of the most important organic compounds, also known as a Schiff base, imine, or
azomethine, has been associated with several biological processes. The group is a …