Type 2B von Willebrand disease (VWD2B) is caused by an abnormal von Willebrand factor
(VWF) with increased affinity for the platelet receptor glycoprotein Ib-α (GPIb-α) that may …

Sequencing of the gene encoding for von Willebrand factor (VWF) has brought new insight
into the physiology of VWF as well as its pathophysiology in the context of von Willebrand …

Background: von Willebrand factor (VWF) does not interact with circulating platelets unless it
is induced to expose the binding site for platelet glycoprotein (GP) Ibα in the A1 domain by …

In type 2B von Willebrand disease, there is spontaneous binding of mutated von Willebrand
factor (VWF) multimers to platelets. Here we report a family in which severe …

Type 2B von Willebrand disease (VWD) is a qualitative type of VWD with a unique feature
among VWD types, resulting from an increased binding of von Willebrand factor (VWF) to its …

Summary Background: Binding of von Willebrand factor (VWF) to platelet GPIbα and to
collagen is attributed to VWF A1 and A3 domains, respectively. Objectives: Using VWF, VWF …

Less than 50 patients are reported with platelet type von Willebrand disease (PT-VWD)
worldwide. Several reports have discussed the diagnostic challenge of this disease versus …

Von Willebrand factor (VWF) binding and platelet adhesion to subendothelial collagens are
initial events in thrombus formation at sites of vascular injury. These events are often studied …

The primary hemostatic von Willebrand factor (vWF) functions to sequester platelets from
rheological blood flow and mediates their adhesion to damaged subendothelium at sites of …

Platelet adhesion and activation through the interaction of von Willebrand factor (VWF) with
platelet glycoprotein (GP) Ibα are the early key events in hemostasis and thrombosis …