The major innate immune cell types involved in tuberculosis (TB) infection are
macrophages, dendritic cells (DCs), neutrophils and natural killer (NK) cells. These immune …

Tuberculosis (TB) caused by the bacterial pathogen Mycobacterium tuberculosis (Mtb)
remains one of the deadliest infectious diseases with over a billion deaths in the past 200 …

In the last two decades, multi (MDR), extensively (XDR), extremely (XXDR) and total (TDR)
drug-resistant Mycobacterium tuberculosis (M. tb) strains have emerged as a threat to public …

Mycobacterium tuberculosis (Mtb), the etiological agent of human tuberculosis (TB), has
plagued humans for thousands of years. TB still remains a major public health problem in …

Tuberculosis (TB) remains one of the greatest threats to human health. The causative
bacterium, Mycobacterium tuberculosis (Mtb), is acquired by the respiratory route. It is …

Cells digest portions of their interiors in a process known as autophagy to recycle nutrients,
remodel and dispose of unwanted cytoplasmic constituents. This ancient pathway …

Macrophages are first-line responders against microbes. The success of Mycobacterium
tuberculosis (Mtb) rests upon its ability to convert these antimicrobial cells into a permissive …

Live Mycobacterium tuberculosis persists in macrophage phagosomes by interfering with
phagolysosome biogenesis. Here, using four-dimensional microscopy and in vitro assays …

Following phagocytosis, the nascent phagosome undergoes maturation to become a
phagolysosome with an acidic, hydrolytic, and often oxidative lumen that can efficiently kill …

▪ Abstract Phagocytosis and phagolysosome biogenesis represent fundamental biological
processes essential for proper tissue homeostasis, development, elimination of invading …