[HTML][HTML] Mechanotransduction in tumor dynamics modeling

B Blanco, H Gomez, J Melchor, R Palma, J Soler… - Physics of Life …, 2023 - Elsevier
Mechanotherapy is a groundbreaking approach to impact carcinogenesis. Cells sense and
respond to mechanical stimuli, translating them into biochemical signals in a process known …

An asymptotic homogenization approach to the microstructural evolution of heterogeneous media

A Ramírez-Torres, S Di Stefano, A Grillo… - International Journal of …, 2018 - Elsevier
In the present work, we apply the asymptotic homogenization technique to the equations
describing the dynamics of a heterogeneous material with evolving micro-structure, thereby …

A formulation of volumetric growth as a mechanical problem subjected to non-holonomic and rheonomic constraint

A Grillo, S Di Stefano - Mathematics and Mechanics of Solids, 2023 - journals.sagepub.com
Starting from a reformulation of the mass balance law based on the Bilby–Kröner–Lee (BKL)
decomposition of the deformation gradient tensor, we study some peculiar mechanical …

In-Silico Modeling of Tumor Spheroid Formation and Growth

M Amereh, R Edwards, M Akbari, B Nadler - Micromachines, 2021 - mdpi.com
Mathematical modeling has significant potential for understanding of biological models of
cancer and to accelerate the progress in cross-disciplinary approaches of cancer treatment …

Growing avascular tumours as elasto-plastic bodies by the theory of evolving natural configurations

C Giverso, M Scianna, A Grillo - Mechanics Research Communications, 2015 - Elsevier
The aim of this article is to propose a simple way of describing a tumour as a linear elastic
material from a reference configuration that is continuously evolving in time due to growth …

In-silico study of asymmetric remodeling of tumors in response to external biochemical stimuli

M Amereh, M Akbari, B Nadler - Scientific Reports, 2023 - nature.com
Among different hallmarks of cancer, understanding biomechanics of tumor growth and
remodeling benefits the most from the theoretical framework of continuum mechanics. Tumor …

A framework for model base hyper-elastic material simulation

AK Bazkiaei, KH Shirazi, M Shishesaz - Journal of Rubber Research, 2020 - Springer
In this research, a framework for modelling and simulation of hyper-elastic materials is
proposed. The framework explains how to employ strain energy functions as a constitutive …

The influence of anisotropic growth and geometry on the stress of solid tumors

A Ramírez-Torres, R Rodríguez-Ramos… - International Journal of …, 2017 - Elsevier
Solid stresses can affect tumor patho-physiology in at least two ways: directly, by
compressing cancer and stromal cells, and indirectly, by deforming blood and lymphatic …

Effective governing equations for heterogenous porous media subject to inhomogeneous body forces

R Penta, A Ramirez Torres, J Merodio… - Mathematics in …, 2021 - eprints.gla.ac.uk
We derive a new homogenized model for heterogeneous porous media driven by
inhomogeneous body forces. We assume that the fine scale, characterizing the …

Mathematical modeling of anisotropic avascular tumor growth

A Ramírez-Torres, R Rodríguez-Ramos… - Mechanics Research …, 2015 - Elsevier
Cancer represents one the most challenging problems in medicine and biology nowadays,
and is being actively addressed by many researchers from different areas of knowledge. The …