Development and prospects of dedicated tracers for the molecular imaging of bacterial infections

A Bunschoten, MM Welling, MF Termaat… - Bioconjugate …, 2013 - ACS Publications
Bacterial infections have always been, and still are, a major global healthcare problem. For
accurate treatment it is of upmost importance that the location (s), severity, type of bacteria …

99mTc‐labeled antibiotics for infection diagnosis: Mechanism, action, and progress

SAR Naqvi - Chemical Biology & Drug Design, 2022 - Wiley Online Library
Discovery of penicillin marked a turning point in the history of infection therapy which also
led to the emergence of bacterial resistance. It is now 100 years to fight with ever‐muted …

Optimization of Artificial Siderophores as 68Ga-Complexed PET Tracers for In Vivo Imaging of Bacterial Infections

C Peukert, LNB Langer, SM Wegener… - Journal of Medicinal …, 2021 - ACS Publications
The diagnosis of bacterial infections at deep body sites benefits from noninvasive imaging of
molecular probes that can be traced by positron emission tomography (PET). We specifically …

Visualizing and quantifying antimicrobial drug distribution in tissue

BA Kuzma, IJ Pence, DA Greenfield, A Ho… - Advanced Drug Delivery …, 2021 - Elsevier
The biodistribution and pharmacokinetics of drugs are vital to the mechanistic understanding
of their efficacy. Measuring antimicrobial drug efficacy has been challenging as plasma drug …

Labeling and biological evaluation of 99m Tc-azithromycin for infective inflammation diagnosis

MH Sanad - Radiochemistry, 2013 - Springer
Azithromycin, an antibiotic used to treat bacterial infections, was labeled with 99 m Tc. The
maximum radiochemical yield of 99 m Tc-azithromycin, 97.5±0.9%, was attained under the …

Radioiodinated famotidine as a new highly selective radiotracer for peptic ulcer disorder detection, diagnostic nuclear imaging and biodistribution

MH Sanad, DH Salama, FA Marzook - Radiochimica Acta, 2017 - degruyter.com
Famotidine was labeled with iodine-125 to obtain 125I-famotidine (125I-fam) as an agent for
ulcer imaging. The radiochemical yield of 125I-famotidine reached approximately …

Radiodiagnosis of peptic ulcer with technetium-99m labeled rabeprazole

MH Sanad, IT Ibrahim - Radiochemistry, 2015 - Springer
Rabeprazole, antiulcer drug, was labeled with 99 m Tc to obtain an agent for ulcer imaging.
The radiochemical yield of 99 m Tc-rabeprazole reaches approximately 98.5±0.4%. The …

Novel radiochemical and biological characterization of 99mTc-histamine as a model for brain imaging

MH Sanad - Journal of Analytical Science and Technology, 2014 - Springer
Background Histamine was successfully labeled with technetium-99 m (99m Tc). The
studied reaction parameters included substrate concentration, reducing agent concentration …

Optimized chromatographic separation and biological evaluation of 99m Tc-clarithromycin for infective inflammation diagnosis

EH Borai, MH Sanad, ASM Fouzy - Radiochemistry, 2016 - Springer
Clarithromycin antibiotic was labeled with technetium-99 m by adding 99 m Tc to
clarithromycin in the presence of SnCl 2· 2H 2 O. The radiochemical yield of 99 m Tc …

Synthesis of 99m Tc-erythromycin complex as a model for infection sites imaging

IY Abdel-Ghaney, MH Sanad - Radiochemistry, 2013 - Springer
Labeling of erythromycin with 99 m Tc using SnCl 2· 2H 2 O as a reducing agent was
investigated. Dependence of the yield of 99 m Tc-erythromycin complex on the …