Tumor suppressor genes cooperate with each other in tumors. Three important tumor
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …

Apoptosis is a cell suicide process that is essential for development, tissue homeostasis and
human health. Impaired apoptosis is associated with a variety of human diseases, including …

Anti-tumorigenic mechanisms mediated by the tumor suppressor p53, upon oncogenic
stresses, are our bodies' greatest weapons to battle against cancer onset and development …

Over 50% cancer bears TP53 mutation, the highly stabilized mutant p53 protein drives the
tumorigenesis and progression. Mutation of p53 not only cause loss-of-function and …

Simple Summary The ubiquitin proteasome system (UPS) governs the non-lysosomal
degradation of oxidized, damaged, or misfolded proteins in eukaryotic cells. Dysregulation …

The tumor suppressor protein p53 participates in the control of key biological functions such
as cell death, metabolic homeostasis and immune function, which are closely related to …

Background Colorectal cancer (CRC) has been ranked as the second most deadly cancer
and the third most diagnosed cancer cases for the year 2020. Specifically for Romania, the …

Regarding the multimechanistic nature of cancers, current chemo‐or radiotherapies often
fail to eradicate disease pathology, and frequent relapses or resistance to therapies occur …

Mdm2 and MdmX are two closely related proteins that have been well-characterized as
negative regulators of the tumor suppressor p53. Their interplay and especially respective …

TP53 mutations are ubiquitous with tumorigenesis in non-small cell lung cancers (NSCLC).
By analyzing the TCGA database, we reported that TP53 missense mutations are correlated …