Parkinson disease (PD) is a progressive neurodegenerative disease that affects peripheral
organs as well as the central nervous system and involves a fundamental role of …

Neurodegenerative disorders like Alzheimer's disease, Huntington's disease, Parkinson's
disease, spinocerebellar ataxias, amyotrophic lateral sclerosis, frontotemporal dementia to …

Parkinson's disease-associated kinase LRRK2 has been linked to IFN type II (IFN-γ)
response in infections and to dopaminergic neuronal loss. However, whether and how …

The molecular mechanisms underlying caudal-to-rostral progression of Lewy body
pathology in Parkinson's disease remain poorly understood. Here, we identified …

In the past few years, there have been a large number of genes identified that contribute to
the lifetime risk of Parkinson's disease (PD). Some genes follow a Mendelian inheritance …

Parkinson's disease (PD) is a common neurodegenerative pathology whose major clinical
symptoms are movement disorders. The main pathological characteristics of PD are the …

Tissue-resident memory CD8 T cells are responsible for local immune surveillance in
different tissues, including the brain. They constitute the first line of defense against …

Imaging biomarkers for immune activation may be valuable for early-stage detection,
therapeutic testing, and research on neurodegenerative conditions. In the present study, we …

Tuberculosis (TB) is the leading cause of death from a single infectious agent. The estimated
total global TB deaths in 2019 were 1.4 million. The decline in TB incidence rate is very …

Cellular function is critically regulated through degradation of substrates by the proteasome.
To enable direct analysis of naturally cleaved proteasomal peptides under physiological …