YAP/TAZ as master regulators in cancer: modulation, function and therapeutic approaches

S Piccolo, T Panciera, P Contessotto, M Cordenonsi - Nature cancer, 2023 - nature.com
Our understanding of the function of the transcriptional regulators YAP and TAZ (YAP/TAZ)
in cancer is advancing. In this Review, we provide an update on recent progress in YAP/TAZ …

The Hippo signalling pathway and its implications in human health and diseases

M Fu, Y Hu, T Lan, KL Guan, T Luo… - Signal transduction and …, 2022 - nature.com
As an evolutionarily conserved signalling network, the Hippo pathway plays a crucial role in
the regulation of numerous biological processes. Thus, substantial efforts have been made …

The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer

R Cunningham, CG Hansen - Clinical Science, 2022 - portlandpress.com
Tumorigenesis is a highly complex process, involving many interrelated and cross-acting
signalling pathways. One such pathway that has garnered much attention in the field of …

YAP/TAZ at the roots of cancer

F Zanconato, M Cordenonsi, S Piccolo - Cancer cell, 2016 - cell.com
YAP and TAZ are highly related transcriptional regulators pervasively activated in human
malignancies. Recent work indicates that, remarkably, YAP/TAZ are essential for cancer …

A TAZ–ANGPTL4–NOX2 Axis regulates ferroptotic cell death and chemoresistance in epithelial ovarian cancer

WH Yang, Z Huang, J Wu, CKC Ding, SK Murphy… - Molecular Cancer …, 2020 - AACR
Ovarian cancer is the deadliest gynecologic cancer. Despite recent advances, clinical
outcomes remain poor, necessitating novel therapeutic approaches. To investigate …

The biology of YAP/TAZ: hippo signaling and beyond

S Piccolo, S Dupont, M Cordenonsi - Physiological reviews, 2014 - journals.physiology.org
The transcriptional regulators YAP and TAZ are the focus of intense interest given their
remarkable biological properties in development, tissue homeostasis and cancer. YAP and …

YAP/TAZ: drivers of tumor growth, metastasis, and resistance to therapy

BJ Thompson - Bioessays, 2020 - Wiley Online Library
The transcriptional co‐activators YAP (or YAP1) and TAZ (or WWTR1) are frequently
activated during the growth and progression of many solid tumors, including lung, colorectal …

Intraovarian control of early folliculogenesis

AJW Hsueh, K Kawamura, Y Cheng… - Endocrine …, 2015 - academic.oup.com
Although hormonal regulation of ovarian follicle development has been extensively
investigated, most studies concentrate on the development of early antral follicles to the …

The Hippo pathway and human cancer

KF Harvey, X Zhang, DM Thomas - Nature Reviews Cancer, 2013 - nature.com
The Hippo pathway controls organ size in diverse species, whereas pathway deregulation
can induce tumours in model organisms and occurs in a broad range of human carcinomas …

The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

R Johnson, G Halder - Nature reviews Drug discovery, 2014 - nature.com
The Hippo signalling pathway is an emerging growth control and tumour suppressor
pathway that regulates cell proliferation and stem cell functions. Defects in Hippo signalling …