The concept of the neurovascular unit (NVU), formalized at the 2001 Stroke Progress
Review Group meeting of the National Institute of Neurological Disorders and Stroke …

Our understanding of the role of the vascular endothelium has evolved over the past 2
decades, with the recognition that it is a dynamically regulated organ and that it plays a …

Brain function critically relies on blood vessels to supply oxygen and nutrients, to establish a
barrier for neurotoxic substances, and to clear waste products. The archetypal vascular …

The development of the nervous and vascular systems constitutes primary events in the
evolution of the animal kingdom; the former provides electrical stimuli and coordination …

At first sight, the nervous and vascular systems seem to share little in common. However,
neural and vascular cells not only are anatomically closely tied to each other, but they also …

Vascular endothelial growth factor-B (VEGF-B), discovered over 15 years ago, has long
been seen as one of the more ambiguous members of the VEGF family. VEGF-B is produced …

Intensive research in the last decade shows that the prototypic angiogenic factor vascular
endothelial growth factor (VEGF) can have direct effects in neurons and modulate processes …

Mounting evidence indicates that the function of members of the vascular endothelial growth
factor (VEGF) family extends beyond blood vessel formation. Here, we show that the …

Aging has been viewed both as a random process due to accumulation of molecular and
cellular damage over time and as a programmed process linked to cellular pathway …

The vascular endothelial growth factor (VEGF)-VEGF receptor (R) system is deeply involved
in angiogenesis and lymphangiogenesis. VEGFR1/Fms-like tyrosine kinase-1 (Flt-1) and …