Prevalence of diabetes, a serious public health problem is rapidly increasing worldwide.
Type-2 diabetes is the common form of diabetes characterized by insulin resistance and …

The pathology of type 2 diabetes is complex, with multiple stages culminating in a functional
β‐cell mass that is insufficient to meet the body's needs. Although the broad outlines of the …

Metformin, as the basic pharmacological therapy and the first preventive drug in type 2
diabetes mellitus (T2DM), is proved to have potential protection in diabetic kidney disease …

The objective of the present study was to develop a rat model that replicates the natural
history and metabolic characteristics of human type 2 diabetes and is also suitable for …

Type 2 diabetes is a complex and heterogeneous disorder presently affecting more than 100
million people worldwide and causing serious socio-economic problems. Appropriate …

Due to the high prevalence of diabetes worldwide, extensive research is still being
performed to develop new antidiabetic agents and determine their mechanisms of action …

Type 2 diabetes mellitus (T2DM) is one of the largest public health problems worldwide.
Insulin resistance-related metabolic dysfunction and chronic hyperglycemia result in …

High‐fat diet (HFD) consumption has been demonstrated to cause peripheral and neuronal
insulin resistance, and brain mitochondrial dysfunction in rats. Although the dipeptidyl …

Background To study the pathogenesis of diabetic cardiomyopathy, reliable animal models
of type 2 diabetes are required. Physiologically relevant rodent models are needed, which …

Type 2 diabetic mellitus is a multifactorial metabolic disorder affecting huge population
around the world. This indicates that there is an urgent unmet need of cost effective, new …