The echinocandins are large lipopeptide molecules that are inhibitors of β-(1, 3)-glucan
synthesis, an action that damages fungal cell walls. In vitro and in vivo, the echinocandins …

The emergence of less common but medically important fungal pathogens contributes to the
rate of morbidity and mortality, especially in the increasingly expanding population of …

Candida species are the most common cause of fungal infections. Candida species produce
infections that range from non—life-threatening mucocutaneous illnesses to invasive …

Background. Invasive candidiasis is an important cause of morbidity and mortality among
patients with health care–associated infection. The echinocandins have potent fungicidal …

Fusarium species frequently implicated in human infections include F. solani, F. oxysporum
and F. moniliforme. Among immunocompetent patients, tissue breakdown (as caused by …

Trichosporonosis is an uncommon but frequently fatal mycosis in immunocompromised
patients. A multicenter retrospective study was conducted to characterize cases of proven or …

Invasive fungal infections are a growing problem in critically ill patients and are associated
with increased morbidity and mortality. Most of them are due to Candida species, especially …

Traditionally, many invasive fungal infections were associated with a poor prognosis,
because effective therapeutic options were limited. The recent development of new …

During the past two decades opportunistic fungal infections have emerged as important
causes of morbidity and mortality in patients with severe underlying illnesses and …

The past few years have seen the advent of several new antifungal agents, including those
of a new class and a new generation of an existing class. Caspofungin, the first available …